Abstract
Purpose: To describe the design and dosimetric characterization of a simple and economical small animal irradiator. Materials and methods: A high dose rate (HDR) 192Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable for hemi-brain irradiation of mice. The unit was equipped with continuous gas anesthesia to allow robust animal immobilization. Dosimetric characterization of the device was performed with Gafchromic film measurements. Results: The tungsten collimator provided a sharp penumbra suitable for hemi-brain irradiation, and dose rates on the order of 200 cGy/minute were achieved. The sharpness of the penumbra attainable with this device compares favorably to those measured experimentally for 6 MV photons, and 6 and 20 MeV electron beams from a linear accelerator, and was comparable to those measured for a 300 kVp orthovoltage beam and a Monte Carlo simulated 90 MeV proton beam. Conclusions: Due to its simplicity and low cost, the apparatus described is an attractive alternative for small animal irradiation experiments requiring steep dose gradients.
Original language | English (US) |
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Pages (from-to) | 936-942 |
Number of pages | 7 |
Journal | International Journal of Radiation Biology |
Volume | 90 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2014 |
Keywords
- Iridium-192 HDR
- Small animal irradiator
- hemi-brain
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging