Design and biocatalytic synthesis of pluronics-based nanomicellar self-assembly systems for drug encapsulation applications

Mukesh K. Pandey, Ke Yang, Cao Pei, Pramod K. Sharma, Joana Viola, Roger Stromberg, Jayant Kumar, Virinder S. Parmar, Arthur C. Watterson

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Nano medicine is an emerging branch of pharmaceuticals, which is gaining considerable attention mainly due to its new and effective way of drug delivery. Various modes of drug delivery are still in their adolescent stage, polymer-based drug delivery system is one among these. In order to develop a novel and biocompatible nano-carrier for drug delivery through a "green" and, environmentally benign approach, herein, we report the design, synthesis and characterization of four novel pluronic-based amphiphilic copolymers. Candida antartica lipase was used to catalyze polymerization in the presence of molecular sieves under solventless conditions. The resulting copolymers were also investigated for their supramolecular organization and drug encapsulation capacity for biomedical applications.

Original languageEnglish (US)
Pages (from-to)788-793
Number of pages6
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume47
Issue number8
DOIs
StatePublished - Aug 1 2010

Keywords

  • Candida antarctica lipase
  • Pluronics
  • amphiphilic polymers
  • curcumin
  • encapsulation

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Design and biocatalytic synthesis of pluronics-based nanomicellar self-assembly systems for drug encapsulation applications'. Together they form a unique fingerprint.

  • Cite this