Design and biocatalytic synthesis of pluronics-based nanomicellar self-assembly systems for drug encapsulation applications

Mukesh Pandey, Ke Yang, Cao Pei, Pramod K. Sharma, Joana Viola, Roger Stromberg, Jayant Kumar, Virinder S. Parmar, Arthur C. Watterson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nano medicine is an emerging branch of pharmaceuticals, which is gaining considerable attention mainly due to its new and effective way of drug delivery. Various modes of drug delivery are still in their adolescent stage, polymer-based drug delivery system is one among these. In order to develop a novel and biocompatible nano-carrier for drug delivery through a "green" and, environmentally benign approach, herein, we report the design, synthesis and characterization of four novel pluronic-based amphiphilic copolymers. Candida antartica lipase was used to catalyze polymerization in the presence of molecular sieves under solventless conditions. The resulting copolymers were also investigated for their supramolecular organization and drug encapsulation capacity for biomedical applications.

Original languageEnglish (US)
Pages (from-to)788-793
Number of pages6
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume47
Issue number8
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Fingerprint

Poloxamer
Drug delivery
Encapsulation
Self assembly
Copolymers
Pharmaceutical Preparations
Medical nanotechnology
Candida
Molecular sieves
Lipases
Lipase
Drug products
Polymers
Polymerization

Keywords

  • amphiphilic polymers
  • Candida antarctica lipase
  • curcumin
  • encapsulation
  • Pluronics

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Design and biocatalytic synthesis of pluronics-based nanomicellar self-assembly systems for drug encapsulation applications. / Pandey, Mukesh; Yang, Ke; Pei, Cao; Sharma, Pramod K.; Viola, Joana; Stromberg, Roger; Kumar, Jayant; Parmar, Virinder S.; Watterson, Arthur C.

In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol. 47, No. 8, 01.08.2010, p. 788-793.

Research output: Contribution to journalArticle

Pandey, Mukesh ; Yang, Ke ; Pei, Cao ; Sharma, Pramod K. ; Viola, Joana ; Stromberg, Roger ; Kumar, Jayant ; Parmar, Virinder S. ; Watterson, Arthur C. / Design and biocatalytic synthesis of pluronics-based nanomicellar self-assembly systems for drug encapsulation applications. In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2010 ; Vol. 47, No. 8. pp. 788-793.
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