Desensitisation of muscarinic receptor-mediated cyclic GMP formation by cultured nerve cells

E. Richelson

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Interest in the interaction of certain psychotropic drugs with muscarinic acetylcholine receptors of cultured nerve cells has led the authors to study the desensitisation of these receptors. They mediate the formation of guanosine 3',5'-cyclic phosphate (cyclic GMP), a response which has yielded much information about the interactions of agonists and antagonists with the muscarinic receptor, although a direct coupling of this receptor and guanylate cyclase has not been demonstrated. The authors report here the use of this receptor effect to characterise the specific desensitisation of muscarinic acetylcholine receptors of intact mouse neuroblastoma cells.

Original languageEnglish (US)
Pages (from-to)366-368
Number of pages3
JournalNature
Volume272
Issue number5651
StatePublished - 1978

ASJC Scopus subject areas

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