Interest in the interaction of certain psychotropic drugs with muscarinic acetylcholine receptors of cultured nerve cells has led the authors to study the desensitisation of these receptors. They mediate the formation of guanosine 3',5'-cyclic phosphate (cyclic GMP), a response which has yielded much information about the interactions of agonists and antagonists with the muscarinic receptor, although a direct coupling of this receptor and guanylate cyclase has not been demonstrated. The authors report here the use of this receptor effect to characterise the specific desensitisation of muscarinic acetylcholine receptors of intact mouse neuroblastoma cells.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 1978|
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