Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1

S. M. Olbricht, Thomas J Flotte, A. B. Collins, C. M. Chapman, T. J. Harrist

Research output: Contribution to journalArticle

Abstract

Dermatitis herpetiformis (DH) is a pruritic papulovesicular skin disorder of unknown cause, characterized by granular IgA deposits in the dermis along the dermoepidermal junction. It is associated with gluten-sensitive enteropathy and increased IgA production by gut lymphoid tissue. We report four cases of immunologically documented DH studied by immunofluorescence technique. Monoclonal antibodies against the IgA subclasses IgA1 and IgA2 were used. IgA1 without IgA2 was found in the cutaneous deposits in each case. The IgA1 had both κ and λ light chains in approximately equal quantities. Because normal gut-associated lymphoid tissue produces 70% IgA1 and 30% IgA2, while circulating IgA is primarily IgA1, it could be concluded that the IgA in the skin of DH patients is not produced in the gut. However, the subclass restriction of the IgA produced by pathologic gut-associated lymphoid tissue is unknown. Alternatively, both IgA1 and IgA2 may be produced by the gut, but only IgA1 is involved in the production of cutaneous lesions.

Original languageEnglish (US)
Pages (from-to)418-421
Number of pages4
JournalArchives of Dermatology
Volume122
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Dermatitis Herpetiformis
Immunoglobulin A
Skin
Lymphoid Tissue

ASJC Scopus subject areas

  • Dermatology

Cite this

Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1. / Olbricht, S. M.; Flotte, Thomas J; Collins, A. B.; Chapman, C. M.; Harrist, T. J.

In: Archives of Dermatology, Vol. 122, No. 4, 1986, p. 418-421.

Research output: Contribution to journalArticle

Olbricht, SM, Flotte, TJ, Collins, AB, Chapman, CM & Harrist, TJ 1986, 'Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1', Archives of Dermatology, vol. 122, no. 4, pp. 418-421. https://doi.org/10.1001/archderm.122.4.418
Olbricht, S. M. ; Flotte, Thomas J ; Collins, A. B. ; Chapman, C. M. ; Harrist, T. J. / Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1. In: Archives of Dermatology. 1986 ; Vol. 122, No. 4. pp. 418-421.
@article{cfb49b5664544510b7a206e529226ad7,
title = "Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1",
abstract = "Dermatitis herpetiformis (DH) is a pruritic papulovesicular skin disorder of unknown cause, characterized by granular IgA deposits in the dermis along the dermoepidermal junction. It is associated with gluten-sensitive enteropathy and increased IgA production by gut lymphoid tissue. We report four cases of immunologically documented DH studied by immunofluorescence technique. Monoclonal antibodies against the IgA subclasses IgA1 and IgA2 were used. IgA1 without IgA2 was found in the cutaneous deposits in each case. The IgA1 had both κ and λ light chains in approximately equal quantities. Because normal gut-associated lymphoid tissue produces 70{\%} IgA1 and 30{\%} IgA2, while circulating IgA is primarily IgA1, it could be concluded that the IgA in the skin of DH patients is not produced in the gut. However, the subclass restriction of the IgA produced by pathologic gut-associated lymphoid tissue is unknown. Alternatively, both IgA1 and IgA2 may be produced by the gut, but only IgA1 is involved in the production of cutaneous lesions.",
author = "Olbricht, {S. M.} and Flotte, {Thomas J} and Collins, {A. B.} and Chapman, {C. M.} and Harrist, {T. J.}",
year = "1986",
doi = "10.1001/archderm.122.4.418",
language = "English (US)",
volume = "122",
pages = "418--421",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "4",

}

TY - JOUR

T1 - Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1

AU - Olbricht, S. M.

AU - Flotte, Thomas J

AU - Collins, A. B.

AU - Chapman, C. M.

AU - Harrist, T. J.

PY - 1986

Y1 - 1986

N2 - Dermatitis herpetiformis (DH) is a pruritic papulovesicular skin disorder of unknown cause, characterized by granular IgA deposits in the dermis along the dermoepidermal junction. It is associated with gluten-sensitive enteropathy and increased IgA production by gut lymphoid tissue. We report four cases of immunologically documented DH studied by immunofluorescence technique. Monoclonal antibodies against the IgA subclasses IgA1 and IgA2 were used. IgA1 without IgA2 was found in the cutaneous deposits in each case. The IgA1 had both κ and λ light chains in approximately equal quantities. Because normal gut-associated lymphoid tissue produces 70% IgA1 and 30% IgA2, while circulating IgA is primarily IgA1, it could be concluded that the IgA in the skin of DH patients is not produced in the gut. However, the subclass restriction of the IgA produced by pathologic gut-associated lymphoid tissue is unknown. Alternatively, both IgA1 and IgA2 may be produced by the gut, but only IgA1 is involved in the production of cutaneous lesions.

AB - Dermatitis herpetiformis (DH) is a pruritic papulovesicular skin disorder of unknown cause, characterized by granular IgA deposits in the dermis along the dermoepidermal junction. It is associated with gluten-sensitive enteropathy and increased IgA production by gut lymphoid tissue. We report four cases of immunologically documented DH studied by immunofluorescence technique. Monoclonal antibodies against the IgA subclasses IgA1 and IgA2 were used. IgA1 without IgA2 was found in the cutaneous deposits in each case. The IgA1 had both κ and λ light chains in approximately equal quantities. Because normal gut-associated lymphoid tissue produces 70% IgA1 and 30% IgA2, while circulating IgA is primarily IgA1, it could be concluded that the IgA in the skin of DH patients is not produced in the gut. However, the subclass restriction of the IgA produced by pathologic gut-associated lymphoid tissue is unknown. Alternatively, both IgA1 and IgA2 may be produced by the gut, but only IgA1 is involved in the production of cutaneous lesions.

UR - http://www.scopus.com/inward/record.url?scp=0022611010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022611010&partnerID=8YFLogxK

U2 - 10.1001/archderm.122.4.418

DO - 10.1001/archderm.122.4.418

M3 - Article

C2 - 3082293

VL - 122

SP - 418

EP - 421

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 4

ER -