Depth electrode studies in temporal lobe epilepsy: Relation to quantitative magnetic resonance imaging and operative outcome

Gregory D Cascino, M. R. Trenerry, F. W. Sharbrough, E. L. So, W. R. Marsh, D. C. Strelow

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We performed a retrospective study of 30 patients with presumed intractable temporal lobe epilepsy (TLE) who underwent chronic intracranial EEG monitoring (CIEM). Multicontact depth electrodes were stereo-tactically implanted through the medial occipital lobe into amygdala and hippocampus. All patients had previously undergone extracranial ictal EEG monitoring that proved inadequate to localize the epileptogenic zone. No morbidity was associated with CIEM in the 30 patients. Twenty-five patients were shown to have exclusively or predominantly unilateral temporal lobe seizures, and 5 patients had bitemporal seizures without unilateral predominance; 24 patients subsequently underwent an anterotemporal lobe cortical resection. Twenty-one patients have been followed a minimum of 1 year postoperatively. Nine patients (43%) had a class I outcome (seizure-free, auras only, or provoked seizures), 3 patients (14%) had a class 11 outcome (≥95% seizure reduction), 4 patients (19%) had a class III outcome (≥50% seizure reduction); and 5 patients (24%) had a class IV outcome (<50% seizure reduction or no change). A prolonged interhemispheric propagation time (p < 0.01) and magnetic resonance imaging (MRI)-identified hippocampal atrophy (p < 0.01) correlated with a favorable surgical outcome. Re-suits of this study may prove useful in counseling patients who undergo CIEM before temporal lobe surgery.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalEpilepsia
Volume36
Issue number3
DOIs
StatePublished - 1995

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Temporal Lobe Epilepsy
Electrodes
Magnetic Resonance Imaging
Seizures
Temporal Lobe
Occipital Lobe
Amygdala
Atrophy
Counseling
Electroencephalography
Epilepsy
Hippocampus
Retrospective Studies
Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Depth electrode studies in temporal lobe epilepsy : Relation to quantitative magnetic resonance imaging and operative outcome. / Cascino, Gregory D; Trenerry, M. R.; Sharbrough, F. W.; So, E. L.; Marsh, W. R.; Strelow, D. C.

In: Epilepsia, Vol. 36, No. 3, 1995, p. 230-235.

Research output: Contribution to journalArticle

Cascino, Gregory D ; Trenerry, M. R. ; Sharbrough, F. W. ; So, E. L. ; Marsh, W. R. ; Strelow, D. C. / Depth electrode studies in temporal lobe epilepsy : Relation to quantitative magnetic resonance imaging and operative outcome. In: Epilepsia. 1995 ; Vol. 36, No. 3. pp. 230-235.
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