Depressive symptoms, vascular risk factors and mild cognitive impairment: The Italian longitudinal study on aging

Francesco Panza, Alessia D'Introno, Anna M. Colacicco, Cristiano Capurso, Angelo Del Parigi, Richard J. Caselli, Orlando Todarello, Vincenza Pellicani, Andrea Santamato, Pierluigi Scapicchio, Stefania Maggi, Emanuele Scafato, Claudia Gandin, Antonio Capurso, Vincenzo Solfrizzi

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85-1.84, χ2 = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.

Original languageEnglish (US)
Pages (from-to)336-346
Number of pages11
JournalDementia and geriatric cognitive disorders
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Dementia
  • Depression
  • Epidemiology
  • Mild cognitive impairment
  • Vascular risk factors, dementia

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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    Panza, F., D'Introno, A., Colacicco, A. M., Capurso, C., Del Parigi, A., Caselli, R. J., Todarello, O., Pellicani, V., Santamato, A., Scapicchio, P., Maggi, S., Scafato, E., Gandin, C., Capurso, A., & Solfrizzi, V. (2008). Depressive symptoms, vascular risk factors and mild cognitive impairment: The Italian longitudinal study on aging. Dementia and geriatric cognitive disorders, 25(4), 336-346. https://doi.org/10.1159/000119522