TY - JOUR
T1 - Depressive symptoms, vascular risk factors and mild cognitive impairment
T2 - The Italian longitudinal study on aging
AU - Panza, Francesco
AU - D'Introno, Alessia
AU - Colacicco, Anna M.
AU - Capurso, Cristiano
AU - Del Parigi, Angelo
AU - Caselli, Richard J.
AU - Todarello, Orlando
AU - Pellicani, Vincenza
AU - Santamato, Andrea
AU - Scapicchio, Pierluigi
AU - Maggi, Stefania
AU - Scafato, Emanuele
AU - Gandin, Claudia
AU - Capurso, Antonio
AU - Solfrizzi, Vincenzo
PY - 2008/4
Y1 - 2008/4
N2 - Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85-1.84, χ2 = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.
AB - Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85-1.84, χ2 = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.
KW - Dementia
KW - Depression
KW - Epidemiology
KW - Mild cognitive impairment
KW - Vascular risk factors, dementia
UR - http://www.scopus.com/inward/record.url?scp=42449146645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42449146645&partnerID=8YFLogxK
U2 - 10.1159/000119522
DO - 10.1159/000119522
M3 - Article
C2 - 18319599
AN - SCOPUS:42449146645
SN - 1420-8008
VL - 25
SP - 336
EP - 346
JO - Dementia and geriatric cognitive disorders
JF - Dementia and geriatric cognitive disorders
IS - 4
ER -