Depressive symptoms in mild cognitive impairment predict greater atrophy in alzheimer's disease-related regions

Grace J. Lee, Po H. Lu, Xue Hua, Suh Lee, Stephanie Wu, Ken Nguyen, Edmond Teng, Alex D. Leow, Clifford R Jr. Jack, Arthur W. Toga, Michael W. Weiner, George Bartzokis, Paul M. Thompson

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background: Depression has been associated with higher conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and may be a marker of prodromal AD that can be used to identify individuals with MCI who are most likely to progress to AD. Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI. Methods: Two-hundred forty-three MCI subjects from the Alzheimer's Disease Neuroimaging Initiative who had brain magnetic resonance imaging scans at baseline and 2-year follow-up were classified into depressed (n = 44), nondepressed with other neuropsychiatric symptoms (n = 93), and no-symptom (NOSYMP; n = 106) groups based on the Neuropsychiatric Inventory Questionnaire. Tensor-based morphometry was used to create individual three-dimensional maps of 2-year brain changes that were compared between groups. Results: Depressed subjects had more frontal (p =.024), parietal (p =.030), and temporal (p =.038) white matter atrophy than NOSYMP subjects. Those whose depressive symptoms persisted over 2 years also had higher conversion to AD and more decline on measures of global cognition, language, and executive functioning compared with stable NOSYMP subjects. Nondepressed with other neuropsychiatric symptoms and NOSYMP groups exhibited no differences in rates of atrophy. Conclusions: Depressive symptoms were associated with greater atrophy in AD-affected regions, increased cognitive decline, and higher rates of conversion to AD. Depression in individuals with MCI may be associated with underlying neuropathological changes, including prodromal AD, and may be a potentially useful clinical marker in identifying MCI patients who are most likely to progress to AD.

Original languageEnglish (US)
Pages (from-to)814-821
Number of pages8
JournalBiological Psychiatry
Volume71
Issue number9
DOIs
StatePublished - May 1 2012

Fingerprint

Atrophy
Alzheimer Disease
Depression
Cognitive Dysfunction
Brain
Neuroimaging
Cognition
Language
Biomarkers
Magnetic Resonance Imaging
Equipment and Supplies

Keywords

  • Alzheimer's disease
  • depression
  • mild cognitive impairment
  • neuropsychiatric symptoms
  • tensor-based morphometry
  • white matter

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Depressive symptoms in mild cognitive impairment predict greater atrophy in alzheimer's disease-related regions. / Lee, Grace J.; Lu, Po H.; Hua, Xue; Lee, Suh; Wu, Stephanie; Nguyen, Ken; Teng, Edmond; Leow, Alex D.; Jack, Clifford R Jr.; Toga, Arthur W.; Weiner, Michael W.; Bartzokis, George; Thompson, Paul M.

In: Biological Psychiatry, Vol. 71, No. 9, 01.05.2012, p. 814-821.

Research output: Contribution to journalArticle

Lee, GJ, Lu, PH, Hua, X, Lee, S, Wu, S, Nguyen, K, Teng, E, Leow, AD, Jack, CRJ, Toga, AW, Weiner, MW, Bartzokis, G & Thompson, PM 2012, 'Depressive symptoms in mild cognitive impairment predict greater atrophy in alzheimer's disease-related regions', Biological Psychiatry, vol. 71, no. 9, pp. 814-821. https://doi.org/10.1016/j.biopsych.2011.12.024
Lee, Grace J. ; Lu, Po H. ; Hua, Xue ; Lee, Suh ; Wu, Stephanie ; Nguyen, Ken ; Teng, Edmond ; Leow, Alex D. ; Jack, Clifford R Jr. ; Toga, Arthur W. ; Weiner, Michael W. ; Bartzokis, George ; Thompson, Paul M. / Depressive symptoms in mild cognitive impairment predict greater atrophy in alzheimer's disease-related regions. In: Biological Psychiatry. 2012 ; Vol. 71, No. 9. pp. 814-821.
@article{e12c201d915e43be890b795e4c6ef911,
title = "Depressive symptoms in mild cognitive impairment predict greater atrophy in alzheimer's disease-related regions",
abstract = "Background: Depression has been associated with higher conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and may be a marker of prodromal AD that can be used to identify individuals with MCI who are most likely to progress to AD. Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI. Methods: Two-hundred forty-three MCI subjects from the Alzheimer's Disease Neuroimaging Initiative who had brain magnetic resonance imaging scans at baseline and 2-year follow-up were classified into depressed (n = 44), nondepressed with other neuropsychiatric symptoms (n = 93), and no-symptom (NOSYMP; n = 106) groups based on the Neuropsychiatric Inventory Questionnaire. Tensor-based morphometry was used to create individual three-dimensional maps of 2-year brain changes that were compared between groups. Results: Depressed subjects had more frontal (p =.024), parietal (p =.030), and temporal (p =.038) white matter atrophy than NOSYMP subjects. Those whose depressive symptoms persisted over 2 years also had higher conversion to AD and more decline on measures of global cognition, language, and executive functioning compared with stable NOSYMP subjects. Nondepressed with other neuropsychiatric symptoms and NOSYMP groups exhibited no differences in rates of atrophy. Conclusions: Depressive symptoms were associated with greater atrophy in AD-affected regions, increased cognitive decline, and higher rates of conversion to AD. Depression in individuals with MCI may be associated with underlying neuropathological changes, including prodromal AD, and may be a potentially useful clinical marker in identifying MCI patients who are most likely to progress to AD.",
keywords = "Alzheimer's disease, depression, mild cognitive impairment, neuropsychiatric symptoms, tensor-based morphometry, white matter",
author = "Lee, {Grace J.} and Lu, {Po H.} and Xue Hua and Suh Lee and Stephanie Wu and Ken Nguyen and Edmond Teng and Leow, {Alex D.} and Jack, {Clifford R Jr.} and Toga, {Arthur W.} and Weiner, {Michael W.} and George Bartzokis and Thompson, {Paul M.}",
year = "2012",
month = "5",
day = "1",
doi = "10.1016/j.biopsych.2011.12.024",
language = "English (US)",
volume = "71",
pages = "814--821",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "9",

}

TY - JOUR

T1 - Depressive symptoms in mild cognitive impairment predict greater atrophy in alzheimer's disease-related regions

AU - Lee, Grace J.

AU - Lu, Po H.

AU - Hua, Xue

AU - Lee, Suh

AU - Wu, Stephanie

AU - Nguyen, Ken

AU - Teng, Edmond

AU - Leow, Alex D.

AU - Jack, Clifford R Jr.

AU - Toga, Arthur W.

AU - Weiner, Michael W.

AU - Bartzokis, George

AU - Thompson, Paul M.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Background: Depression has been associated with higher conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and may be a marker of prodromal AD that can be used to identify individuals with MCI who are most likely to progress to AD. Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI. Methods: Two-hundred forty-three MCI subjects from the Alzheimer's Disease Neuroimaging Initiative who had brain magnetic resonance imaging scans at baseline and 2-year follow-up were classified into depressed (n = 44), nondepressed with other neuropsychiatric symptoms (n = 93), and no-symptom (NOSYMP; n = 106) groups based on the Neuropsychiatric Inventory Questionnaire. Tensor-based morphometry was used to create individual three-dimensional maps of 2-year brain changes that were compared between groups. Results: Depressed subjects had more frontal (p =.024), parietal (p =.030), and temporal (p =.038) white matter atrophy than NOSYMP subjects. Those whose depressive symptoms persisted over 2 years also had higher conversion to AD and more decline on measures of global cognition, language, and executive functioning compared with stable NOSYMP subjects. Nondepressed with other neuropsychiatric symptoms and NOSYMP groups exhibited no differences in rates of atrophy. Conclusions: Depressive symptoms were associated with greater atrophy in AD-affected regions, increased cognitive decline, and higher rates of conversion to AD. Depression in individuals with MCI may be associated with underlying neuropathological changes, including prodromal AD, and may be a potentially useful clinical marker in identifying MCI patients who are most likely to progress to AD.

AB - Background: Depression has been associated with higher conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and may be a marker of prodromal AD that can be used to identify individuals with MCI who are most likely to progress to AD. Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI. Methods: Two-hundred forty-three MCI subjects from the Alzheimer's Disease Neuroimaging Initiative who had brain magnetic resonance imaging scans at baseline and 2-year follow-up were classified into depressed (n = 44), nondepressed with other neuropsychiatric symptoms (n = 93), and no-symptom (NOSYMP; n = 106) groups based on the Neuropsychiatric Inventory Questionnaire. Tensor-based morphometry was used to create individual three-dimensional maps of 2-year brain changes that were compared between groups. Results: Depressed subjects had more frontal (p =.024), parietal (p =.030), and temporal (p =.038) white matter atrophy than NOSYMP subjects. Those whose depressive symptoms persisted over 2 years also had higher conversion to AD and more decline on measures of global cognition, language, and executive functioning compared with stable NOSYMP subjects. Nondepressed with other neuropsychiatric symptoms and NOSYMP groups exhibited no differences in rates of atrophy. Conclusions: Depressive symptoms were associated with greater atrophy in AD-affected regions, increased cognitive decline, and higher rates of conversion to AD. Depression in individuals with MCI may be associated with underlying neuropathological changes, including prodromal AD, and may be a potentially useful clinical marker in identifying MCI patients who are most likely to progress to AD.

KW - Alzheimer's disease

KW - depression

KW - mild cognitive impairment

KW - neuropsychiatric symptoms

KW - tensor-based morphometry

KW - white matter

UR - http://www.scopus.com/inward/record.url?scp=84862776747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862776747&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2011.12.024

DO - 10.1016/j.biopsych.2011.12.024

M3 - Article

C2 - 22322105

AN - SCOPUS:84862776747

VL - 71

SP - 814

EP - 821

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 9

ER -