Depressive behaviour in children diagnosed with a mitochondrial disorder

E. Morava; T. Gardeitchik; T. Kozicz; L. de Boer; S. Koene; M. C. de Vries; R. McFarland; T. Roobol; R. J.T. Rodenburg; C. M. Verhaak

doi:10.1016/j.mito.2010.05.011

Depressive behaviour in children diagnosed with a mitochondrial disorder

E. Morava, T. Gardeitchik, T. Kozicz, L. de Boer, S. Koene, M. C. de Vries, R. McFarland, T. Roobol, R. J.T. Rodenburg, C. M. Verhaak

Medical Genetics

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A higher incidence of depression has been described in adults with primary oxidative phosphorylation disease. We evaluated the psychological characteristics of eighteen non-retarded pediatric patients diagnosed with a disorder of the oxidative phosphorylation. We found significantly higher rate of withdrawn, depressive behaviour compared to population norm scores, to children with other types of inborn errors of metabolism and also in comparison to patients with Sotos syndrome. The occurrence of depressive behaviour showed no correlation with the degree of mitochondrial dysfunction. These findings support the hypothesis that mood disorders could be associated to abnormal cerebral energy metabolism.

Original language	English (US)
Pages (from-to)	528-533
Number of pages	6
Journal	Mitochondrion
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/j.mito.2010.05.011
State	Published - Aug 2010

Keywords

Child behavioral checklist
Depression
Depressive behaviour
Mitochondrial medicine
Oxidative phosphorylation

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

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10.1016/j.mito.2010.05.011

Cite this

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title = "Depressive behaviour in children diagnosed with a mitochondrial disorder",

abstract = "A higher incidence of depression has been described in adults with primary oxidative phosphorylation disease. We evaluated the psychological characteristics of eighteen non-retarded pediatric patients diagnosed with a disorder of the oxidative phosphorylation. We found significantly higher rate of withdrawn, depressive behaviour compared to population norm scores, to children with other types of inborn errors of metabolism and also in comparison to patients with Sotos syndrome. The occurrence of depressive behaviour showed no correlation with the degree of mitochondrial dysfunction. These findings support the hypothesis that mood disorders could be associated to abnormal cerebral energy metabolism.",

keywords = "Child behavioral checklist, Depression, Depressive behaviour, Mitochondrial medicine, Oxidative phosphorylation",

author = "E. Morava and T. Gardeitchik and T. Kozicz and {de Boer}, L. and S. Koene and {de Vries}, {M. C.} and R. McFarland and T. Roobol and Rodenburg, {R. J.T.} and Verhaak, {C. M.}",

note = "Funding Information: E.M. acknowledges the support of the Tjallingh Roorda Foundation. T.K. would like to acknowledge the Nederlands Organization for Scientific Research NWO (#864.05.008) for support of this work. Appendix A ",

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doi = "10.1016/j.mito.2010.05.011",

language = "English (US)",

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journal = "Mitochondrion",

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T1 - Depressive behaviour in children diagnosed with a mitochondrial disorder

AU - Morava, E.

AU - Gardeitchik, T.

AU - Kozicz, T.

AU - de Boer, L.

AU - Koene, S.

AU - de Vries, M. C.

AU - McFarland, R.

AU - Roobol, T.

AU - Rodenburg, R. J.T.

AU - Verhaak, C. M.

N1 - Funding Information: E.M. acknowledges the support of the Tjallingh Roorda Foundation. T.K. would like to acknowledge the Nederlands Organization for Scientific Research NWO (#864.05.008) for support of this work. Appendix A

PY - 2010/8

Y1 - 2010/8

N2 - A higher incidence of depression has been described in adults with primary oxidative phosphorylation disease. We evaluated the psychological characteristics of eighteen non-retarded pediatric patients diagnosed with a disorder of the oxidative phosphorylation. We found significantly higher rate of withdrawn, depressive behaviour compared to population norm scores, to children with other types of inborn errors of metabolism and also in comparison to patients with Sotos syndrome. The occurrence of depressive behaviour showed no correlation with the degree of mitochondrial dysfunction. These findings support the hypothesis that mood disorders could be associated to abnormal cerebral energy metabolism.

AB - A higher incidence of depression has been described in adults with primary oxidative phosphorylation disease. We evaluated the psychological characteristics of eighteen non-retarded pediatric patients diagnosed with a disorder of the oxidative phosphorylation. We found significantly higher rate of withdrawn, depressive behaviour compared to population norm scores, to children with other types of inborn errors of metabolism and also in comparison to patients with Sotos syndrome. The occurrence of depressive behaviour showed no correlation with the degree of mitochondrial dysfunction. These findings support the hypothesis that mood disorders could be associated to abnormal cerebral energy metabolism.

KW - Child behavioral checklist

KW - Depression

KW - Depressive behaviour

KW - Mitochondrial medicine

KW - Oxidative phosphorylation

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JF - Mitochondrion

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Depressive behaviour in children diagnosed with a mitochondrial disorder

Abstract

Keywords

ASJC Scopus subject areas

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