Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy

Eduardo E. Benarroch, Ann M. Schmeichel, Joseph E. Parisi

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 ± 2 vs 81 ± 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 ± 3 vs 47 ± 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.

Original languageEnglish (US)
Pages (from-to)944-946
Number of pages3
JournalNeurology
Volume59
Issue number6
DOIs
StatePublished - Sep 24 2002

ASJC Scopus subject areas

  • Clinical Neurology

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