Denervation of the extrinsic cardiac sympathetic nervous system as a treatment modality for arrhythmia

Chance M. Witt, Luciana Bolona, Michelle O. Kinney, Christopher Moir, Michael John Ackerman, Suraj Kapa, Samuel J Asirvatham, Christopher J. McLeod

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Denervation of the extrinsic cardiac sympathetic nervous system is a method of altering the autonomic tone experienced by the heart and vasculature. It has been studied and employed as a therapy for cardiac disease for decades. Currently, there is a high level of interest in using cardiac denervation for treatment of arrhythmias. This review describes the anatomy and physiology of the cardiac autonomic nervous system followed by a discussion of the mechanistic studies which provide a basis for the therapeutic use of sympathetic denervation. The clinical research supporting its use in human arrhythmias is then appraised, covering the standard indications, such as long QT syndrome, as well as future possibilities. Last, a detailed account of the methods for performing surgical cardiac denervation and percutaneous stellate ganglion anesthetic block is provided, including the complications of each procedure. An understanding of the anatomy and physiology of the cardiac autonomic nervous system along with the techniques of surgical denervation and percutaneous anesthetic block will allow the clinician to effectively discuss and implement these therapies.

Original languageEnglish (US)
Pages (from-to)1075-1083
Number of pages9
JournalEuropace
Volume19
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Sympathetic Nervous System
Denervation
Cardiac Arrhythmias
Autonomic Nervous System
Anesthetics
Anatomy
Stellate Ganglion
Long QT Syndrome
Sympathectomy
Therapeutic Uses
Heart Diseases
Therapeutics
Research

Keywords

  • Arrhythmia
  • Autonomic nervous system
  • Cardiac sympathetic denervation
  • Stellate ganglion block
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Denervation of the extrinsic cardiac sympathetic nervous system as a treatment modality for arrhythmia. / Witt, Chance M.; Bolona, Luciana; Kinney, Michelle O.; Moir, Christopher; Ackerman, Michael John; Kapa, Suraj; Asirvatham, Samuel J; McLeod, Christopher J.

In: Europace, Vol. 19, No. 7, 01.07.2017, p. 1075-1083.

Research output: Contribution to journalReview article

Witt, Chance M. ; Bolona, Luciana ; Kinney, Michelle O. ; Moir, Christopher ; Ackerman, Michael John ; Kapa, Suraj ; Asirvatham, Samuel J ; McLeod, Christopher J. / Denervation of the extrinsic cardiac sympathetic nervous system as a treatment modality for arrhythmia. In: Europace. 2017 ; Vol. 19, No. 7. pp. 1075-1083.
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