Abstract
In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.
Original language | English (US) |
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Article number | e1162896 |
Journal | Molecular and Cellular Oncology |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Jul 3 2016 |
Keywords
- Ageing
- mTOR
- mitochondria
- senescence
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research