In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.
|Original language||English (US)|
|Journal||Molecular and Cellular Oncology|
|State||Published - Jul 3 2016|
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research