Demonstration of T200 on human Langerhans cell surface membranes

Thomas J Flotte, G. F. Murphy, A. K. Bhan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We have demonstrated the presence of the glycoprotein T200 on the surface of human epidermal Langerhans and indeterminate cells by immunoelectron microscopy with the use of a monoclonal antibody. No other epidermal cells were positive. The presence of T200 on Langerhans cells confirms their hematopoietic origin because T200 is limited to hematopoietic cells and neoplasms. Although the function of T200 is not known, antibodies directed against T200 have been previously shown to inhibit accessory cell and natural killer cell activities. While the existence of a possible relationship between Langerhans cells and natural killer cells is unclear, Langerhans cells are important in cutaneous accessory cell functions; therefore, T200 may be important in understanding the biology of Langerhans cells and their relationship to other cells in the immune response.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalJournal of Investigative Dermatology
Volume82
Issue number5
StatePublished - 1984
Externally publishedYes

Fingerprint

Langerhans Cells
Accessories
Demonstrations
Cell Membrane
Membranes
Glycoproteins
Microscopic examination
Natural Killer Cells
Monoclonal Antibodies
Antibodies
Immunoelectron Microscopy
Hematologic Neoplasms
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Demonstration of T200 on human Langerhans cell surface membranes. / Flotte, Thomas J; Murphy, G. F.; Bhan, A. K.

In: Journal of Investigative Dermatology, Vol. 82, No. 5, 1984, p. 535-537.

Research output: Contribution to journalArticle

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