Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer model

Ianko D. Iankov, Pavlos Msaouel, Cory Allen, Mark J. Federspiel, Peggy A. Bulur, Allan B. Dietz, Dennis Gastineau, Yasuhiro Ikeda, James N. Ingle, Stephen J. Russell, Evanthia Galanis

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Breast cancer is the second leading cause of malignant effusions in cancer patients. Pleural effusion indicates incurable disease with limited palliative treatment options and poor outcome. Here, we demonstrate the therapeutic efficacy of measles virus (MV) vaccine strain derivative against malignant pleural effusion in an MDA-MB-231 xenograft model of advanced breast cancer. Both systemic intravenous (i.v.) and intrapleural (t.t.) administered virus caused massive infection and syncytia formation in the pleural tumor deposits. Intrapleural administration of 1.5 × 106 plaque-forming units (PFU) total dose of MV significantly improved median survival by approximately 80% compared to the control animal group. Furthermore, we tested human dendritic cells as carriers for delivery of oncolytic MV infection to breast cancer pleural metastases. Carrier-delivered MV infection prevented accumulation of the pleural exudate and also significantly improved the survival of the treated mice. This is the first demonstration of the therapeutic potential of oncolytic virotherapy against malignant pleural effusions in a pre-clinical model of advanced breast cancer.

Original languageEnglish (US)
Pages (from-to)745-754
Number of pages10
JournalBreast Cancer Research and Treatment
Volume122
Issue number3
DOIs
StatePublished - Aug 2010

Keywords

  • Breast cancer
  • Measles virus
  • Oncolytic virotherapy
  • Pleural effusion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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