Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades

S. J. Taler, E. E. Messersmith, A. B. Leichtman, B. W. Gillespie, C. E. Kew, M. D. Stegall, R. M. Merion, A. J. Matas, H. N. Ibrahim

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

While cautious criteria for selection of living kidney donors are credited for favorable outcomes, recent practice changes may include acceptance of less than ideal donors. To characterize trends in donor acceptance, the Renal and Lung Living Donors Evaluation (RELIVE) Study evaluated 8,951 kidney donors who donated between 1963 and 2007 at three major U.S. transplant centers. Over the study interval, there was an increase in the percentage of donors >40 years old from 38% to 51%; donors >60 years varied between 1% and 4%. The proportion of donors with obesity increased from 8% to 26% and with glucose intolerance from 9% to 25%. The percentage of hypertensive donors was consistent (5-8%). Accepted donors ≥60 years old were more likely to have obesity, glucose intolerance, and/or hypertension compared to younger donors (p<0.0001). Our results demonstrate important trends in acceptance of older and more obese donors. The fraction of older donors accepted with glucose intolerance or hypertension remains small and for the majority includes mild elevations in glucose or blood pressure that were previously classified as within normal limits. The Renal and Lung Living Donors Evaluation (RELIVE) Study reports explosive growth in numbers of living kidney donors, particularly those between 41-60 years old; a 25% increase in the percentage of patients with obesity or glucose intolerance; steady, low rates of hypertension; and trends to higher median values for BMI, fasting glucose, and systolic blood pressure over five decades.

Original languageEnglish (US)
Pages (from-to)390-398
Number of pages9
JournalAmerican Journal of Transplantation
Volume13
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Glucose intolerance
  • hypertension
  • living kidney donor
  • metabolic characteristics
  • obesity
  • trends

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Taler, S. J., Messersmith, E. E., Leichtman, A. B., Gillespie, B. W., Kew, C. E., Stegall, M. D., Merion, R. M., Matas, A. J., & Ibrahim, H. N. (2013). Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades. American Journal of Transplantation, 13(2), 390-398. https://doi.org/10.1111/j.1600-6143.2012.04321.x