Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species

Michelle M Mielke, Veera Venkata Ratnam Bandaru, Dingfen Han, Yang An, Susan M. Resnick, Luigi Ferrucci, Norman J. Haughey

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

It has been increasingly recognized at the basic science level that perturbations in ceramide metabolism are associated with the development and progression of many age-related diseases. However, the translation of this work to the clinic has lagged behind. Understanding the factors longitudinally associated with plasma ceramides and dihydroceramides (DHCer) at the population level and how these lipid levels change with age, and by sex, is important for the clinical development of future therapeutics and biomarkers focused on ceramide metabolism. We, therefore, examined factors cross-sectionally and longitudinally associated with plasma concentrations of ceramides and DHCer among Baltimore Longitudinal Study of Aging participants (n = 992; 3960 total samples), aged 55 years and older, with plasma at a mean of 4.1 visits (range 2-6). Quantitative analyses were performed on a high-performance liquid chromatography-coupled electrospray ionization tandem mass spectrometer. Linear mixed models were used to assess the relationships between plasma ceramide and DHCer species and demographics, diseases, medications, and lifestyle factors. Women had higher plasma concentrations of most ceramide and DHCer species and showed steeper trajectories of age-related increases compared to men. Ceramides and DHCer were more associated with waist-hip ratio than body mass index. Plasma cholesterol and triglycerides, prediabetes, and diabetes were associated with ceramides and DHCer, but the relationship showed specificity to the acyl chain length and saturation. These results demonstrate the importance of examining the individual species of ceramides and DHCer, and of establishing whether intra-individual age- and sex-specific changes occur in synchrony to disease onset and progression.

Original languageEnglish (US)
Pages (from-to)1014-1023
Number of pages10
JournalAging Cell
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Ceramides
Demography
dihydroceramide
Prediabetic State
Baltimore
Waist-Hip Ratio
Longitudinal Studies
Disease Progression
Life Style
Linear Models
Triglycerides
Body Mass Index
Biomarkers
Cholesterol
High Pressure Liquid Chromatography
Lipids

Keywords

  • Aging
  • Ceramide
  • Dihydroceramide
  • Human
  • Longitudinal
  • Sex differences

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. / Mielke, Michelle M; Bandaru, Veera Venkata Ratnam; Han, Dingfen; An, Yang; Resnick, Susan M.; Ferrucci, Luigi; Haughey, Norman J.

In: Aging Cell, Vol. 14, No. 6, 01.12.2015, p. 1014-1023.

Research output: Contribution to journalArticle

Mielke, Michelle M ; Bandaru, Veera Venkata Ratnam ; Han, Dingfen ; An, Yang ; Resnick, Susan M. ; Ferrucci, Luigi ; Haughey, Norman J. / Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. In: Aging Cell. 2015 ; Vol. 14, No. 6. pp. 1014-1023.
@article{37eec19ae3e64ed18e94505a95dddffa,
title = "Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species",
abstract = "It has been increasingly recognized at the basic science level that perturbations in ceramide metabolism are associated with the development and progression of many age-related diseases. However, the translation of this work to the clinic has lagged behind. Understanding the factors longitudinally associated with plasma ceramides and dihydroceramides (DHCer) at the population level and how these lipid levels change with age, and by sex, is important for the clinical development of future therapeutics and biomarkers focused on ceramide metabolism. We, therefore, examined factors cross-sectionally and longitudinally associated with plasma concentrations of ceramides and DHCer among Baltimore Longitudinal Study of Aging participants (n = 992; 3960 total samples), aged 55 years and older, with plasma at a mean of 4.1 visits (range 2-6). Quantitative analyses were performed on a high-performance liquid chromatography-coupled electrospray ionization tandem mass spectrometer. Linear mixed models were used to assess the relationships between plasma ceramide and DHCer species and demographics, diseases, medications, and lifestyle factors. Women had higher plasma concentrations of most ceramide and DHCer species and showed steeper trajectories of age-related increases compared to men. Ceramides and DHCer were more associated with waist-hip ratio than body mass index. Plasma cholesterol and triglycerides, prediabetes, and diabetes were associated with ceramides and DHCer, but the relationship showed specificity to the acyl chain length and saturation. These results demonstrate the importance of examining the individual species of ceramides and DHCer, and of establishing whether intra-individual age- and sex-specific changes occur in synchrony to disease onset and progression.",
keywords = "Aging, Ceramide, Dihydroceramide, Human, Longitudinal, Sex differences",
author = "Mielke, {Michelle M} and Bandaru, {Veera Venkata Ratnam} and Dingfen Han and Yang An and Resnick, {Susan M.} and Luigi Ferrucci and Haughey, {Norman J.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1111/acel.12369",
language = "English (US)",
volume = "14",
pages = "1014--1023",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species

AU - Mielke, Michelle M

AU - Bandaru, Veera Venkata Ratnam

AU - Han, Dingfen

AU - An, Yang

AU - Resnick, Susan M.

AU - Ferrucci, Luigi

AU - Haughey, Norman J.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - It has been increasingly recognized at the basic science level that perturbations in ceramide metabolism are associated with the development and progression of many age-related diseases. However, the translation of this work to the clinic has lagged behind. Understanding the factors longitudinally associated with plasma ceramides and dihydroceramides (DHCer) at the population level and how these lipid levels change with age, and by sex, is important for the clinical development of future therapeutics and biomarkers focused on ceramide metabolism. We, therefore, examined factors cross-sectionally and longitudinally associated with plasma concentrations of ceramides and DHCer among Baltimore Longitudinal Study of Aging participants (n = 992; 3960 total samples), aged 55 years and older, with plasma at a mean of 4.1 visits (range 2-6). Quantitative analyses were performed on a high-performance liquid chromatography-coupled electrospray ionization tandem mass spectrometer. Linear mixed models were used to assess the relationships between plasma ceramide and DHCer species and demographics, diseases, medications, and lifestyle factors. Women had higher plasma concentrations of most ceramide and DHCer species and showed steeper trajectories of age-related increases compared to men. Ceramides and DHCer were more associated with waist-hip ratio than body mass index. Plasma cholesterol and triglycerides, prediabetes, and diabetes were associated with ceramides and DHCer, but the relationship showed specificity to the acyl chain length and saturation. These results demonstrate the importance of examining the individual species of ceramides and DHCer, and of establishing whether intra-individual age- and sex-specific changes occur in synchrony to disease onset and progression.

AB - It has been increasingly recognized at the basic science level that perturbations in ceramide metabolism are associated with the development and progression of many age-related diseases. However, the translation of this work to the clinic has lagged behind. Understanding the factors longitudinally associated with plasma ceramides and dihydroceramides (DHCer) at the population level and how these lipid levels change with age, and by sex, is important for the clinical development of future therapeutics and biomarkers focused on ceramide metabolism. We, therefore, examined factors cross-sectionally and longitudinally associated with plasma concentrations of ceramides and DHCer among Baltimore Longitudinal Study of Aging participants (n = 992; 3960 total samples), aged 55 years and older, with plasma at a mean of 4.1 visits (range 2-6). Quantitative analyses were performed on a high-performance liquid chromatography-coupled electrospray ionization tandem mass spectrometer. Linear mixed models were used to assess the relationships between plasma ceramide and DHCer species and demographics, diseases, medications, and lifestyle factors. Women had higher plasma concentrations of most ceramide and DHCer species and showed steeper trajectories of age-related increases compared to men. Ceramides and DHCer were more associated with waist-hip ratio than body mass index. Plasma cholesterol and triglycerides, prediabetes, and diabetes were associated with ceramides and DHCer, but the relationship showed specificity to the acyl chain length and saturation. These results demonstrate the importance of examining the individual species of ceramides and DHCer, and of establishing whether intra-individual age- and sex-specific changes occur in synchrony to disease onset and progression.

KW - Aging

KW - Ceramide

KW - Dihydroceramide

KW - Human

KW - Longitudinal

KW - Sex differences

UR - http://www.scopus.com/inward/record.url?scp=84954375577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954375577&partnerID=8YFLogxK

U2 - 10.1111/acel.12369

DO - 10.1111/acel.12369

M3 - Article

C2 - 26193443

AN - SCOPUS:84954375577

VL - 14

SP - 1014

EP - 1023

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 6

ER -