Demographic and clinical characteristics associated with glomerular filtration rates in living kidney donors

Emilio D. Poggio, Andrew D. Rule, Roberto Tanchanco, Susana Arrigain, Robert S. Butler, Titte Srinivas, Brian R. Stephany, Kathryn H. Meyer, Saul Nurko, Richard A. Fatica, Daniel A. Shoskes, Venkatesh Krishnamurthi, David A. Goldfarb, Inderbir Gill, Martin J. Schreiber

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Due to the shortage of organs, living donor acceptance criteria are becoming less stringent. An accurate determination of the glomerular filtration rate (GFR) is critical in the evaluation of living kidney donors and a value exceeding 80ml min per 1.73m2 is usually considered suitable. To improve strategies for kidney donor screening, an understanding of factors that affect GFR is needed. Here we studied the relationships between donor GFR measured by 125I-iothalamate clearances (mGFR) and age, gender, race, and decade of care in living kidney donors evaluated at the Cleveland Clinic from 1972 to 2005. We report the normal reference ranges for 1057 prospective donors (56 female, 11 African American). Females had slightly higher mGFR than males after adjustment for body surface area, but there were no differences due to race. The lower limit of normal for donors (5th percentile) was less than 80ml min per 1.73m2 for females over age 45 and for males over age 40. We found a significant doubling in the rate of GFR decline in donors over age 45 as compared to younger donors. The age of the donors and body mass index increased over time, but their mGFR, adjusted for body surface area, significantly declined by 1.49±0.61ml min per 1.73m2 per decade of testing. Our study shows that age and gender are important factors determining normal GFR in living kidney donors.

Original languageEnglish (US)
Pages (from-to)1079-1087
Number of pages9
JournalKidney international
Volume75
Issue number10
DOIs
StatePublished - May 2009

Keywords

  • Age
  • GFR
  • Gender
  • Living donor
  • MDRD
  • Race

ASJC Scopus subject areas

  • Nephrology

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    Poggio, E. D., Rule, A. D., Tanchanco, R., Arrigain, S., Butler, R. S., Srinivas, T., Stephany, B. R., Meyer, K. H., Nurko, S., Fatica, R. A., Shoskes, D. A., Krishnamurthi, V., Goldfarb, D. A., Gill, I., & Schreiber, M. J. (2009). Demographic and clinical characteristics associated with glomerular filtration rates in living kidney donors. Kidney international, 75(10), 1079-1087. https://doi.org/10.1038/ki.2009.11