Dementia with Lewy Bodies

Tanis J. Ferman; Bradley F. Boeve

doi:10.1016/j.ncl.2007.03.001

Dementia with Lewy Bodies

Tanis J. Ferman, Bradley F. Boeve

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neurocognitive patterns, psychiatric features, extrapyramidal signs, and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion and type/distribution of neuropathology contribute to these clinical differences.

Original language	English (US)
Pages (from-to)	741-760
Number of pages	20
Journal	Neurologic clinics
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.ncl.2007.03.001
State	Published - Aug 2007

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2007.03.001

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title = "Dementia with Lewy Bodies",

abstract = "The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neurocognitive patterns, psychiatric features, extrapyramidal signs, and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion and type/distribution of neuropathology contribute to these clinical differences.",

author = "Ferman, {Tanis J.} and Boeve, {Bradley F.}",

note = "Funding Information: Supported by NIH grants R01-AG15866, P50-AG16574, and P50-NS40256. ",

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AU - Ferman, Tanis J.

AU - Boeve, Bradley F.

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PY - 2007/8

Y1 - 2007/8

N2 - The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neurocognitive patterns, psychiatric features, extrapyramidal signs, and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion and type/distribution of neuropathology contribute to these clinical differences.

AB - The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neurocognitive patterns, psychiatric features, extrapyramidal signs, and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion and type/distribution of neuropathology contribute to these clinical differences.

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JO - Neurologic clinics

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Dementia with Lewy Bodies

Abstract

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