Dementia with Lewy Bodies

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neurocognitive patterns, psychiatric features, extrapyramidal signs, and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion and type/distribution of neuropathology contribute to these clinical differences.

Original languageEnglish (US)
Pages (from-to)741-760
Number of pages20
JournalNeurologic clinics
Volume25
Issue number3
DOIs
StatePublished - Aug 1 2007

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Dementia with Lewy Bodies'. Together they form a unique fingerprint.

  • Cite this