Dementia with Lewy bodies

Ian McKeith, Jacobo Mintzer, Dag Aarsland, David Burn, Helen Chiu, Jiska Cohen-Mansfield, Dennis Dickson, Bruno Dubois, John E. Duda, Howard Feldman, Serge Gauthier, Glenda Halliday, Brian Lawlor, Carol Lippa, Oscar L. Lopez, João Carlos MacHado, John O'Brien, Jeremy Playfer, Wayne Reid

Research output: Contribution to journalReview article

576 Scopus citations

Abstract

Dementia with Lewy bodies (DLB) is the second commonest cause of neurodegenerative dementia in older people. It is part of the range of clinical presentations that share a neuritic pathology based on abnormal aggregation of the synaptic protein α-synuclein. DLB has many of the clinical and pathological characteristics of the dementia that occurs during the course of Parkinson's disease. Here we review the current state of scientific knowledge on DLB. Accurate identification of patients is important because they have specific symptoms, impairments, and functional disabilities that differ from those of other common types of dementia. Severe neuroleptic sensitivity reactions are associated with significantly increased morbidity and mortality. Treatment with cholinesterase inhibitors is well tolerated by most patients and substantially improves cognitive and neuropsychiatric symptoms. Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalLancet Neurology
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Clinical Neurology

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    McKeith, I., Mintzer, J., Aarsland, D., Burn, D., Chiu, H., Cohen-Mansfield, J., Dickson, D., Dubois, B., Duda, J. E., Feldman, H., Gauthier, S., Halliday, G., Lawlor, B., Lippa, C., Lopez, O. L., Carlos MacHado, J., O'Brien, J., Playfer, J., & Reid, W. (2004). Dementia with Lewy bodies. Lancet Neurology, 3(1), 19-28. https://doi.org/10.1016/S1474-4422(03)00619-7