Dementia occurring over a 32-year follow-up attributable to hypertension observed at different ages: Implications for dementia prevention

Jason R. Smith, A. Richey Sharrett, James Russel Pike, Rebecca F. Gottesman, David S. Knopman, Mark Lee, Pamela L. Lutsey, Priya Palta, B. Gwen Windham, Josef Coresh, Jennifer A. Deal

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: The fraction of dementia attributable to hypertension might vary depending on the age of the population considered and the age through which dementia occurs. METHODS: In the Atherosclerosis Risk in Communities study, we quantified population attributable fractions (PAF) of dementia by age 80 and 90 from hypertension assessed at ages of 45–54 (n = 7572), 55–64 (n = 12,033), 65–74 (n = 6561), and 75–84 (n = 2086). RESULTS: The PAF for dementia by age 80 from all non-normal blood pressure at ages 45–54 was 15.3% (95% confidence interval [CI] = 6.9%–22.3%), 19.1% (95% CI = 9.9%–26.9%) at ages 55–64, and 19.9% (95% CI = −4.4%–38.5%) at ages 65–74. The strongest PAFs were from stage 2 hypertension (11.9%–21.3%). For dementia by age 90, PAFs from non-normal blood pressure up through age 75 were smaller (10.9%–13.8%), and non-significant by age 75–84. DISCUSSION: Interventions targeting hypertension even in early late life might reduce a sizeable proportion of dementia. Highlights: We estimated prospective population attributable risks of dementia for hypertension. 15%–20% of dementia cases by age 80 are from non-normal blood pressure (BP). Associations between hypertension and dementia persisted through age 75. Midlife to early late-life BP control might reduce a large proportion of dementia.

Original languageEnglish (US)
Pages (from-to)3435-3447
Number of pages13
JournalAlzheimer's and Dementia
Volume19
Issue number8
DOIs
StatePublished - Aug 2023

Keywords

  • cognitive impairment
  • cohort study
  • population attributable fraction
  • public health
  • vascular risk factor

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

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