Dementia in MS complicated by coexistent Alzheimer disease: Diagnosis premortem and postmortem

Eoin P. Flanagan; David S. Knopman; B. Mark Keegan

doi:10.1212/CPJ.0000000000000030

Dementia in MS complicated by coexistent Alzheimer disease: Diagnosis premortem and postmortem

Eoin P. Flanagan, David S. Knopman, B. Mark Keegan

Neurology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Distinguishing dementia due to multiple sclerosis (MS) from that of an accompanying neurodegenerative dementia coexisting with MS has been difficult. The recent introduction of Alzheimer disease (AD) biomarkers of amyloid-b and neuronal degeneration has improved diagnosis of AD premortem. We describe 3 patients with MS with coexisting AD, 1 diagnosed at autopsy before AD biomarkers were available and 2 diagnosed premortem by decreased CSF amyloid-b1-42/tau index, MRI, and 18F-flourodeoxyglucose-PET patterns. AD biomarkers may be of diagnostic value in selected patients with severe dementia and MS.

Original language	English (US)
Pages (from-to)	226-230
Number of pages	5
Journal	Neurology: Clinical Practice
Volume	4
Issue number	3
DOIs	https://doi.org/10.1212/CPJ.0000000000000030
State	Published - Jun 2014

ASJC Scopus subject areas

Clinical Neurology

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10.1212/CPJ.0000000000000030

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title = "Dementia in MS complicated by coexistent Alzheimer disease: Diagnosis premortem and postmortem",

abstract = "Distinguishing dementia due to multiple sclerosis (MS) from that of an accompanying neurodegenerative dementia coexisting with MS has been difficult. The recent introduction of Alzheimer disease (AD) biomarkers of amyloid-b and neuronal degeneration has improved diagnosis of AD premortem. We describe 3 patients with MS with coexisting AD, 1 diagnosed at autopsy before AD biomarkers were available and 2 diagnosed premortem by decreased CSF amyloid-b1-42/tau index, MRI, and 18F-flourodeoxyglucose-PET patterns. AD biomarkers may be of diagnostic value in selected patients with severe dementia and MS.",

author = "Flanagan, {Eoin P.} and Knopman, {David S.} and Keegan, {B. Mark}",

year = "2014",

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AU - Flanagan, Eoin P.

AU - Knopman, David S.

AU - Keegan, B. Mark

PY - 2014/6

Y1 - 2014/6

N2 - Distinguishing dementia due to multiple sclerosis (MS) from that of an accompanying neurodegenerative dementia coexisting with MS has been difficult. The recent introduction of Alzheimer disease (AD) biomarkers of amyloid-b and neuronal degeneration has improved diagnosis of AD premortem. We describe 3 patients with MS with coexisting AD, 1 diagnosed at autopsy before AD biomarkers were available and 2 diagnosed premortem by decreased CSF amyloid-b1-42/tau index, MRI, and 18F-flourodeoxyglucose-PET patterns. AD biomarkers may be of diagnostic value in selected patients with severe dementia and MS.

AB - Distinguishing dementia due to multiple sclerosis (MS) from that of an accompanying neurodegenerative dementia coexisting with MS has been difficult. The recent introduction of Alzheimer disease (AD) biomarkers of amyloid-b and neuronal degeneration has improved diagnosis of AD premortem. We describe 3 patients with MS with coexisting AD, 1 diagnosed at autopsy before AD biomarkers were available and 2 diagnosed premortem by decreased CSF amyloid-b1-42/tau index, MRI, and 18F-flourodeoxyglucose-PET patterns. AD biomarkers may be of diagnostic value in selected patients with severe dementia and MS.

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Dementia in MS complicated by coexistent Alzheimer disease: Diagnosis premortem and postmortem

Abstract

ASJC Scopus subject areas

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