Dementia in MS complicated by coexistent Alzheimer disease: Diagnosis premortem and postmortem

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Distinguishing dementia due to multiple sclerosis (MS) from that of an accompanying neurodegenerative dementia coexisting with MS has been difficult. The recent introduction of Alzheimer disease (AD) biomarkers of amyloid-b and neuronal degeneration has improved diagnosis of AD premortem. We describe 3 patients with MS with coexisting AD, 1 diagnosed at autopsy before AD biomarkers were available and 2 diagnosed premortem by decreased CSF amyloid-b1-42/tau index, MRI, and 18F-flourodeoxyglucose-PET patterns. AD biomarkers may be of diagnostic value in selected patients with severe dementia and MS.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalNeurology: Clinical Practice
Volume4
Issue number3
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Clinical Neurology

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