Dementia and the TAR DNA binding protein 43

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Recently, another protein, the transactive response DNA binding protein of 43 kDa (TDP-43), was discovered to play a major role in frontotemporal lobar degeneration (FTLD), a group of diseases associated with young-onset dementia. TDP-43 has now been linked to more than 10 diseases, including amyotrophic lateral sclerosis (ALS).

Original languageEnglish (US)
Pages (from-to)555-558
Number of pages4
JournalClinical Pharmacology and Therapeutics
Volume88
Issue number4
DOIs
StatePublished - Oct 2010

Fingerprint

DNA-Binding Proteins
Dementia
Synucleins
Frontotemporal Lobar Degeneration
Proteins
Microtubule-Associated Proteins
Amyotrophic Lateral Sclerosis
Amyloid

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Dementia and the TAR DNA binding protein 43. / Josephs, Keith Anthony.

In: Clinical Pharmacology and Therapeutics, Vol. 88, No. 4, 10.2010, p. 555-558.

Research output: Contribution to journalArticle

@article{b472197332024e8fb1c2eb0a199912c0,
title = "Dementia and the TAR DNA binding protein 43",
abstract = "Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Recently, another protein, the transactive response DNA binding protein of 43 kDa (TDP-43), was discovered to play a major role in frontotemporal lobar degeneration (FTLD), a group of diseases associated with young-onset dementia. TDP-43 has now been linked to more than 10 diseases, including amyotrophic lateral sclerosis (ALS).",
author = "Josephs, {Keith Anthony}",
year = "2010",
month = "10",
doi = "10.1038/clpt.2010.112",
language = "English (US)",
volume = "88",
pages = "555--558",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Dementia and the TAR DNA binding protein 43

AU - Josephs, Keith Anthony

PY - 2010/10

Y1 - 2010/10

N2 - Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Recently, another protein, the transactive response DNA binding protein of 43 kDa (TDP-43), was discovered to play a major role in frontotemporal lobar degeneration (FTLD), a group of diseases associated with young-onset dementia. TDP-43 has now been linked to more than 10 diseases, including amyotrophic lateral sclerosis (ALS).

AB - Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Recently, another protein, the transactive response DNA binding protein of 43 kDa (TDP-43), was discovered to play a major role in frontotemporal lobar degeneration (FTLD), a group of diseases associated with young-onset dementia. TDP-43 has now been linked to more than 10 diseases, including amyotrophic lateral sclerosis (ALS).

UR - http://www.scopus.com/inward/record.url?scp=77957018786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957018786&partnerID=8YFLogxK

U2 - 10.1038/clpt.2010.112

DO - 10.1038/clpt.2010.112

M3 - Article

C2 - 20739922

AN - SCOPUS:77957018786

VL - 88

SP - 555

EP - 558

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 4

ER -