Dementia and the TAR DNA binding protein 43

Keith Anthony Josephs

doi:10.1038/clpt.2010.112

Dementia and the TAR DNA binding protein 43

Keith Anthony Josephs

Neurology

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Recently, another protein, the transactive response DNA binding protein of 43 kDa (TDP-43), was discovered to play a major role in frontotemporal lobar degeneration (FTLD), a group of diseases associated with young-onset dementia. TDP-43 has now been linked to more than 10 diseases, including amyotrophic lateral sclerosis (ALS).

Original language	English (US)
Pages (from-to)	555-558
Number of pages	4
Journal	Clinical Pharmacology and Therapeutics
Volume	88
Issue number	4
DOIs	https://doi.org/10.1038/clpt.2010.112
State	Published - Oct 2010

Fingerprint

DNA-Binding Proteins

Dementia

Synucleins

Frontotemporal Lobar Degeneration

Proteins

Microtubule-Associated Proteins

Amyotrophic Lateral Sclerosis

Amyloid

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Medicine(all)

Cite this

Josephs, K. A. (2010). Dementia and the TAR DNA binding protein 43. Clinical Pharmacology and Therapeutics, 88(4), 555-558. https://doi.org/10.1038/clpt.2010.112

Dementia and the TAR DNA binding protein 43. / Josephs, Keith Anthony.

In: Clinical Pharmacology and Therapeutics, Vol. 88, No. 4, 10.2010, p. 555-558.

Research output: Contribution to journal › Article

Josephs, KA 2010, 'Dementia and the TAR DNA binding protein 43', Clinical Pharmacology and Therapeutics, vol. 88, no. 4, pp. 555-558. https://doi.org/10.1038/clpt.2010.112

Josephs KA. Dementia and the TAR DNA binding protein 43. Clinical Pharmacology and Therapeutics. 2010 Oct;88(4):555-558. https://doi.org/10.1038/clpt.2010.112

Josephs, Keith Anthony. / Dementia and the TAR DNA binding protein 43. In: Clinical Pharmacology and Therapeutics. 2010 ; Vol. 88, No. 4. pp. 555-558.

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10.1038/clpt.2010.112