TY - JOUR
T1 - Dementia and the TAR DNA binding protein 43
AU - Josephs, K. A.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Recently, another protein, the transactive response DNA binding protein of 43 kDa (TDP-43), was discovered to play a major role in frontotemporal lobar degeneration (FTLD), a group of diseases associated with young-onset dementia. TDP-43 has now been linked to more than 10 diseases, including amyotrophic lateral sclerosis (ALS).
AB - Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Recently, another protein, the transactive response DNA binding protein of 43 kDa (TDP-43), was discovered to play a major role in frontotemporal lobar degeneration (FTLD), a group of diseases associated with young-onset dementia. TDP-43 has now been linked to more than 10 diseases, including amyotrophic lateral sclerosis (ALS).
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U2 - 10.1038/clpt.2010.112
DO - 10.1038/clpt.2010.112
M3 - Review article
C2 - 20739922
AN - SCOPUS:77957018786
VL - 88
SP - 555
EP - 558
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 4
ER -