Dementia and low testosterone and bioavailable testosterone levels in men: Possible increased risk

Sri Suravarapu, Eric J. Bergstralh, Sara A. Farmer, David S. Knopman, Steven J. Jacobsen, Rosebud O. Roberts

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This study examines associations of serum total and bioavailable testosterone (T) with dementia in a community-based cohort of men. Study subjects (n=128; ages 65 y and older at baseline) were recruited in 1990 and followed through 2006. Dementia was assessed from the subject medical records on the basis of the criteria from the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Serum from a blood draw performed in 1994 was assayed for total and bioavailable T. Twenty-one men developed dementia over 1186 person-years of follow-up. The cumulative incidence of dementia was 14.7% in men with total T <410 ng/mL (median) and 8.0% in men with higher levels [≥ 410 ng/mL; age-adjusted hazard ratio (HR)=2.09; 95% confidence interval (CI)=0.76, 5.75]. Similarly, the cumulative incidence of dementia was 18.8% in men with bioavailable T <12 ng/mL (median) and 2.2% in men with bioavailable T 12 ng/mL; age-adjusted HR=1.22 (95% CI=0.38, 3.87). These findings do not demonstrate a significant association between T levels and dementia. However, they suggest a need for further investigation of these potential associations.

Original languageEnglish (US)
Pages (from-to)138-140
Number of pages3
JournalAlzheimer disease and associated disorders
Volume20
Issue number3
DOIs
StatePublished - Jul 1 2006

Keywords

  • Alzheimer disease
  • Cohort study
  • Dementia
  • Epidemiology
  • Testosterone

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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