Delta-selective ligands related to naltrindole

David Daniels, P. S. Portoghese

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Opioid antagonists have been crucial as pharmacological tools in opioid research [1]. Historically, the ability of naloxone or naltrexone to reversibly antagonize an opioid agonist effect in an apparently competitive fashion was an important criterion for establishing the involvement of an opioid receptormediated effect. Naloxone and naltrexone are useful in this regard because they are universal antagonists; that is, they are able to antagonize the agonist effects mediated through multiple opioid receptors. However, because these ligands possess low selectivity, they are not useful for investigating the pharmacology mediated through specific opioid receptor types. Consequently, an armamentarium of highly selective opioid antagonists is now available for this purpose. Such antagonists have been invaluable for determining the selectivity of opioid ligands and opioid receptor mechanisms. In this chapter we focus on the rationale for the design of nonpeptide, deltaselective opioid antagonists related to naltrindole and their utility as pharmacological tools.

Original languageEnglish (US)
Title of host publicationThe Delta Receptor
PublisherCRC Press
Pages139-158
Number of pages20
ISBN (Electronic)9780203025765
ISBN (Print)9780824740313
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

naltrindole
Opioid Analgesics
Narcotic Antagonists
Opioid Receptors
Ligands
Naltrexone
Pharmacology
Naloxone
Research

ASJC Scopus subject areas

  • Neuroscience(all)
  • Health Professions(all)
  • Medicine(all)

Cite this

Daniels, D., & Portoghese, P. S. (2003). Delta-selective ligands related to naltrindole. In The Delta Receptor (pp. 139-158). CRC Press.

Delta-selective ligands related to naltrindole. / Daniels, David; Portoghese, P. S.

The Delta Receptor. CRC Press, 2003. p. 139-158.

Research output: Chapter in Book/Report/Conference proceedingChapter

Daniels, D & Portoghese, PS 2003, Delta-selective ligands related to naltrindole. in The Delta Receptor. CRC Press, pp. 139-158.
Daniels D, Portoghese PS. Delta-selective ligands related to naltrindole. In The Delta Receptor. CRC Press. 2003. p. 139-158
Daniels, David ; Portoghese, P. S. / Delta-selective ligands related to naltrindole. The Delta Receptor. CRC Press, 2003. pp. 139-158
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