Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance

Marina Boccardi; Martina Bocchetta; Liana G. Apostolova; Josephine Barnes; George Bartzokis; Gabriele Corbetta; Charles Decarli; Leyla Detoledo-Morrell; Michael Firbank; Rossana Ganzola; Lotte Gerritsen; Wouter Henneman; Ronald J. Killiany; Nikolai Malykhin; Patrizio Pasqualetti; Jens C. Pruessner; Alberto Redolfi; Nicolas Robitaille; Hilkka Soininen; Daniele Tolomeo; Lei Wang; Craig Watson; Henrike Wolf; Henri Duvernoy; Simon Duchesne; Clifford R. Jack; Giovanni B. Frisoni

doi:10.1016/j.jalz.2014.02.009

Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance

Marina Boccardi, Martina Bocchetta, Liana G. Apostolova, Josephine Barnes, George Bartzokis, Gabriele Corbetta, Charles Decarli, Leyla Detoledo-Morrell, Michael Firbank, Rossana Ganzola, Lotte Gerritsen, Wouter Henneman, Ronald J. Killiany, Nikolai Malykhin, Patrizio Pasqualetti, Jens C. Pruessner, Alberto Redolfi, Nicolas Robitaille, Hilkka Soininen, Daniele TolomeoLei Wang, Craig Watson, Henrike Wolf, Henri Duvernoy, Simon Duchesne, Clifford R. Jack, Giovanni B. Frisoni

Radiology

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Background: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation. Methods: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests. Results: Agreement was significant on the inclusion of alveus/fimbria (P 5.021), whole hippocampal tail (P 5.013), medial border of the body according to visible morphology (P 5.0006), and on this combined set of features (P 5.001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates. Discussion: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

Original language	English (US)
Pages (from-to)	126-138
Number of pages	13
Journal	Alzheimer's and Dementia
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.jalz.2014.02.009
State	Published - 2015

Keywords

Alzheimer's disease
Anatomical landmarks
Atrophy
Delphi procedure
Enrichment
Harmonization
Hippocampal atrophy
Hippocampus
MCI
Magnetic resonance
Manual segmentation
Medial temporal lobe
Neuroimaging
Reliability
Standard operational procedures
Volumetry

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2014.02.009

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Boccardi, M., Bocchetta, M., Apostolova, L. G., Barnes, J., Bartzokis, G., Corbetta, G., Decarli, C., Detoledo-Morrell, L., Firbank, M., Ganzola, R., Gerritsen, L., Henneman, W., Killiany, R. J., Malykhin, N., Pasqualetti, P., Pruessner, J. C., Redolfi, A., Robitaille, N., Soininen, H., ... Frisoni, G. B. (2015). Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance. Alzheimer's and Dementia, 11(2), 126-138. https://doi.org/10.1016/j.jalz.2014.02.009

Boccardi, M, Bocchetta, M, Apostolova, LG, Barnes, J, Bartzokis, G, Corbetta, G, Decarli, C, Detoledo-Morrell, L, Firbank, M, Ganzola, R, Gerritsen, L, Henneman, W, Killiany, RJ, Malykhin, N, Pasqualetti, P, Pruessner, JC, Redolfi, A, Robitaille, N, Soininen, H, Tolomeo, D, Wang, L, Watson, C, Wolf, H, Duvernoy, H, Duchesne, S, Jack, CR & Frisoni, GB 2015, 'Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance', Alzheimer's and Dementia, vol. 11, no. 2, pp. 126-138. https://doi.org/10.1016/j.jalz.2014.02.009

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title = "Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance",

abstract = "Background: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation. Methods: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests. Results: Agreement was significant on the inclusion of alveus/fimbria (P 5.021), whole hippocampal tail (P 5.013), medial border of the body according to visible morphology (P 5.0006), and on this combined set of features (P 5.001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates. Discussion: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.",

keywords = "Alzheimer's disease, Anatomical landmarks, Atrophy, Delphi procedure, Enrichment, Harmonization, Hippocampal atrophy, Hippocampus, MCI, Magnetic resonance, Manual segmentation, Medial temporal lobe, Neuroimaging, Reliability, Standard operational procedures, Volumetry",

author = "Marina Boccardi and Martina Bocchetta and Apostolova, {Liana G.} and Josephine Barnes and George Bartzokis and Gabriele Corbetta and Charles Decarli and Leyla Detoledo-Morrell and Michael Firbank and Rossana Ganzola and Lotte Gerritsen and Wouter Henneman and Killiany, {Ronald J.} and Nikolai Malykhin and Patrizio Pasqualetti and Pruessner, {Jens C.} and Alberto Redolfi and Nicolas Robitaille and Hilkka Soininen and Daniele Tolomeo and Lei Wang and Craig Watson and Henrike Wolf and Henri Duvernoy and Simon Duchesne and Jack, {Clifford R.} and Frisoni, {Giovanni B.}",

year = "2015",

doi = "10.1016/j.jalz.2014.02.009",

language = "English (US)",

volume = "11",

pages = "126--138",

journal = "Alzheimer's and Dementia",

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TY - JOUR

T1 - Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance

AU - Boccardi, Marina

AU - Bocchetta, Martina

AU - Apostolova, Liana G.

AU - Barnes, Josephine

AU - Bartzokis, George

AU - Corbetta, Gabriele

AU - Decarli, Charles

AU - Detoledo-Morrell, Leyla

AU - Firbank, Michael

AU - Ganzola, Rossana

AU - Gerritsen, Lotte

AU - Henneman, Wouter

AU - Killiany, Ronald J.

AU - Malykhin, Nikolai

AU - Pasqualetti, Patrizio

AU - Pruessner, Jens C.

AU - Redolfi, Alberto

AU - Robitaille, Nicolas

AU - Soininen, Hilkka

AU - Tolomeo, Daniele

AU - Wang, Lei

AU - Watson, Craig

AU - Wolf, Henrike

AU - Duvernoy, Henri

AU - Duchesne, Simon

AU - Jack, Clifford R.

AU - Frisoni, Giovanni B.

PY - 2015

Y1 - 2015

N2 - Background: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation. Methods: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests. Results: Agreement was significant on the inclusion of alveus/fimbria (P 5.021), whole hippocampal tail (P 5.013), medial border of the body according to visible morphology (P 5.0006), and on this combined set of features (P 5.001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates. Discussion: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

AB - Background: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation. Methods: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests. Results: Agreement was significant on the inclusion of alveus/fimbria (P 5.021), whole hippocampal tail (P 5.013), medial border of the body according to visible morphology (P 5.0006), and on this combined set of features (P 5.001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates. Discussion: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.

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KW - Anatomical landmarks

KW - Atrophy

KW - Delphi procedure

KW - Enrichment

KW - Harmonization

KW - Hippocampal atrophy

KW - Hippocampus

KW - MCI

KW - Magnetic resonance

KW - Manual segmentation

KW - Medial temporal lobe

KW - Neuroimaging

KW - Reliability

KW - Standard operational procedures

KW - Volumetry

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DO - 10.1016/j.jalz.2014.02.009

M3 - Article

C2 - 25130658

AN - SCOPUS:84933532565

SN - 1552-5260

VL - 11

SP - 126

EP - 138

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance

Abstract

Keywords

ASJC Scopus subject areas

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