Delivering the message

Epimorphin and mammary epithelial morphogenesis

Derek C Radisky, Yohei Hirai, Mina J. Bissell

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The mammary gland consists of a highly branched tubular epithelium surrounded by a complex mesenchymal stroma. Epimorphin is an extracellular protein that is expressed by mammary mesenchymal cells that directs epithelial morphogenesis. Depending upon the context of presentation - polar versus apolar - epimorphin can selectively direct two key processes of tubulogenesis: branching morphogenesis (processes involved in tubule initiation and extension) and luminal morphogenesis (required for enlargement of tubule caliber). Here, we outline the fundamentals of mammary gland development and describe the function of epimorphin in these processes. We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs.

Original languageEnglish (US)
Pages (from-to)426-434
Number of pages9
JournalTrends in Cell Biology
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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Morphogenesis
Breast
Human Mammary Glands
Epithelium
Epithelial Cells
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Delivering the message : Epimorphin and mammary epithelial morphogenesis. / Radisky, Derek C; Hirai, Yohei; Bissell, Mina J.

In: Trends in Cell Biology, Vol. 13, No. 8, 01.08.2003, p. 426-434.

Research output: Contribution to journalArticle

Radisky, Derek C ; Hirai, Yohei ; Bissell, Mina J. / Delivering the message : Epimorphin and mammary epithelial morphogenesis. In: Trends in Cell Biology. 2003 ; Vol. 13, No. 8. pp. 426-434.
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