Deliberative assessment of surrogate consent in dementia research

Scott Y H Kim, Rebecca A. Uhlmann, Paul S. Appelbaum, David S Knopman, H. Myra Kim, Laura Damschroder, Elizabeth Beattie, Laura Struble, Raymond De Vries

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Research involving incapacitated persons with dementia entails complex scientific, legal, and ethical issues, making traditional surveys of layperson views on the ethics of such research challenging. We therefore assessed the impact of democratic deliberation (DD), involving balanced, detailed education and peer deliberation, on the views of those responsible for persons with dementia. Methods: One hundred and seventy-eight community-recruited caregivers or primary decision-makers for persons with dementia were randomly assigned to either an all-day DD session group or a control group. Educational materials used for the DD session were vetted for balance and accuracy by an interdisciplinary advisory panel. We assessed the acceptability of family-surrogate consent for dementia research ("surrogate-based research") from a societal policy perspective as well as from the more personal perspectives of deciding for a loved one or for oneself (surrogate and self-perspectives), assessed at baseline, immediately post-DD session, and 1 month after DD date, for four research scenarios of varying risk-benefit profiles. Results: At baseline, a majority in both the DD and control groups supported a policy of family consent for dementia research in all research scenarios. The support for a policy of family consent for surrogate-based research increased in the DD group, but not in the control group. The change in the DD group was maintained 1 month later. In the DD group, there were transient changes in attitudes from surrogate or self-perspectives. In the control group, there were no changes from baseline in attitude toward surrogate consent from any perspective. Conclusions: Intensive, balanced, and accurate education, along with peer deliberation provided by democratic deliberation, led to a sustained increase in support for a societal policy of family consent in dementia research among those responsible for dementia patients.

Original languageEnglish (US)
Pages (from-to)342-350
Number of pages9
JournalAlzheimer's and Dementia
Volume6
Issue number4
DOIs
StatePublished - Jul 2010

Fingerprint

Dementia
Family Planning Policy
Research
Control Groups
Research Ethics
Education
Ethics
Caregivers

Keywords

  • Alzheimer's disease
  • Bioethics
  • Deliberative democracy
  • Impaired decision-making capacity
  • Informed consent
  • Research ethics
  • Surrogate-based research

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology
  • Medicine(all)

Cite this

Kim, S. Y. H., Uhlmann, R. A., Appelbaum, P. S., Knopman, D. S., Kim, H. M., Damschroder, L., ... De Vries, R. (2010). Deliberative assessment of surrogate consent in dementia research. Alzheimer's and Dementia, 6(4), 342-350. https://doi.org/10.1016/j.jalz.2009.06.001

Deliberative assessment of surrogate consent in dementia research. / Kim, Scott Y H; Uhlmann, Rebecca A.; Appelbaum, Paul S.; Knopman, David S; Kim, H. Myra; Damschroder, Laura; Beattie, Elizabeth; Struble, Laura; De Vries, Raymond.

In: Alzheimer's and Dementia, Vol. 6, No. 4, 07.2010, p. 342-350.

Research output: Contribution to journalArticle

Kim, SYH, Uhlmann, RA, Appelbaum, PS, Knopman, DS, Kim, HM, Damschroder, L, Beattie, E, Struble, L & De Vries, R 2010, 'Deliberative assessment of surrogate consent in dementia research', Alzheimer's and Dementia, vol. 6, no. 4, pp. 342-350. https://doi.org/10.1016/j.jalz.2009.06.001
Kim, Scott Y H ; Uhlmann, Rebecca A. ; Appelbaum, Paul S. ; Knopman, David S ; Kim, H. Myra ; Damschroder, Laura ; Beattie, Elizabeth ; Struble, Laura ; De Vries, Raymond. / Deliberative assessment of surrogate consent in dementia research. In: Alzheimer's and Dementia. 2010 ; Vol. 6, No. 4. pp. 342-350.
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