Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

Eduardo Nunes Chini; Claudia C.S. Chini; Veronica Nin; Carlos Escande

doi:10.1042/BSR20130062

Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

Eduardo Nunes Chini, Claudia C.S. Chini, Veronica Nin, Carlos Escande

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging 'hallmark' of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.

Original language	English (US)
Article number	e00058
Pages (from-to)	637-643
Number of pages	7
Journal	Bioscience reports
Volume	33
Issue number	4
DOIs	https://doi.org/10.1042/BSR20130062
State	Published - 2013

Keywords

Aging
Cancer
Circadian cycle
Deleted in breast cancer-1 (DBC1)
Epigenetics
Histone deacetylase (HDAC)
Metabolism

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1042/BSR20130062

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abstract = "DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging 'hallmark' of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.",

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AU - Escande, Carlos

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AB - DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging 'hallmark' of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.

KW - Aging

KW - Cancer

KW - Circadian cycle

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Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

Abstract

Keywords

ASJC Scopus subject areas

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