Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

Eduardo Nunes Chini, Claudia C.S. Chini, Veronica Nin, Carlos Escande

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging 'hallmark' of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.

Original languageEnglish (US)
Article numbere00058
Pages (from-to)637-643
Number of pages7
JournalBioscience reports
Volume33
Issue number4
DOIs
StatePublished - 2013

Keywords

  • Aging
  • Cancer
  • Circadian cycle
  • Deleted in breast cancer-1 (DBC1)
  • Epigenetics
  • Histone deacetylase (HDAC)
  • Metabolism

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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