TY - JOUR
T1 - Delayed pulmonary fibrosis after nitrosourea therapy
AU - Limper, Andrew H.
AU - Mcdonald, John A.
PY - 1990/8/9
Y1 - 1990/8/9
N2 - Adverse pulmonary reactions resulting from the use of chemotherapeutic agents are a life-threatening complication of modern cancer therapy. Their recognition and differentiation from lung injuries with infectious or other causes present a continuing diagnostic challenge to physicians treating patients with cancer. Many commonly used chemotherapeutic agents cause pulmonary injury and fibrosis. Until now, bleomycin has been the prototype, with fibrosis occurring in approximately 10 percent of patients receiving this agent, in whom it is fatal in roughly 10 percent.1 Adverse pulmonary reactions have also been associated with other cytotoxic agents, including busulfan, cyclophosphamide, chlorambucil, methotrexate, cytarabine, and the nitrosourea compounds;.
AB - Adverse pulmonary reactions resulting from the use of chemotherapeutic agents are a life-threatening complication of modern cancer therapy. Their recognition and differentiation from lung injuries with infectious or other causes present a continuing diagnostic challenge to physicians treating patients with cancer. Many commonly used chemotherapeutic agents cause pulmonary injury and fibrosis. Until now, bleomycin has been the prototype, with fibrosis occurring in approximately 10 percent of patients receiving this agent, in whom it is fatal in roughly 10 percent.1 Adverse pulmonary reactions have also been associated with other cytotoxic agents, including busulfan, cyclophosphamide, chlorambucil, methotrexate, cytarabine, and the nitrosourea compounds;.
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U2 - 10.1056/NEJM199008093230609
DO - 10.1056/NEJM199008093230609
M3 - Editorial
C2 - 2370891
AN - SCOPUS:0025296923
SN - 0028-4793
VL - 323
SP - 407
EP - 409
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 6
ER -