Delayed mammary tumor progression in Muc-1 null mice

Andrew P. Spicer, Gerald J. Rowse, Thomas K. Lidner, Sandra J Gendler

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

The mucin gene, Muc-1, encodes a high molecular weight integral membrane glycoprotein that is present on the apical surface of most simple secretory epithelial cells. Muc-1 is highly expressed and aberrantly glycosylated by most carcinomas and metastatic lesions. Numerous functions have been proposed for this molecule, including protection of the epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor progression. Mice deficient in Muc-1 were generated using homologous recombination in embryonic stem cells. These mice appeared to develop normally and were healthy and fertile. However, the growth rate of primary breast tumors induced by polyoma middle T antigen was found to be significantly slower in Muc-1 deficient mice. This suggests that Muc-1 plays an important role in the progression of mammary carcinoma.

Original languageEnglish (US)
Pages (from-to)30093-30101
Number of pages9
JournalJournal of Biological Chemistry
Volume270
Issue number50
DOIs
StatePublished - Dec 15 1995

Fingerprint

Tumors
Breast Neoplasms
Viral Tumor Antigens
Membrane Glycoproteins
Mucins
Stem cells
Epithelial Cells
Organogenesis
Genes
Homologous Recombination
Molecular weight
Embryonic Stem Cells
Molecules
Molecular Weight
Carcinoma
Growth
Neoplasms

ASJC Scopus subject areas

  • Biochemistry

Cite this

Delayed mammary tumor progression in Muc-1 null mice. / Spicer, Andrew P.; Rowse, Gerald J.; Lidner, Thomas K.; Gendler, Sandra J.

In: Journal of Biological Chemistry, Vol. 270, No. 50, 15.12.1995, p. 30093-30101.

Research output: Contribution to journalArticle

Spicer, Andrew P. ; Rowse, Gerald J. ; Lidner, Thomas K. ; Gendler, Sandra J. / Delayed mammary tumor progression in Muc-1 null mice. In: Journal of Biological Chemistry. 1995 ; Vol. 270, No. 50. pp. 30093-30101.
@article{44fe0ba0702c41c88c0b55686a2769f1,
title = "Delayed mammary tumor progression in Muc-1 null mice",
abstract = "The mucin gene, Muc-1, encodes a high molecular weight integral membrane glycoprotein that is present on the apical surface of most simple secretory epithelial cells. Muc-1 is highly expressed and aberrantly glycosylated by most carcinomas and metastatic lesions. Numerous functions have been proposed for this molecule, including protection of the epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor progression. Mice deficient in Muc-1 were generated using homologous recombination in embryonic stem cells. These mice appeared to develop normally and were healthy and fertile. However, the growth rate of primary breast tumors induced by polyoma middle T antigen was found to be significantly slower in Muc-1 deficient mice. This suggests that Muc-1 plays an important role in the progression of mammary carcinoma.",
author = "Spicer, {Andrew P.} and Rowse, {Gerald J.} and Lidner, {Thomas K.} and Gendler, {Sandra J}",
year = "1995",
month = "12",
day = "15",
doi = "10.1074/jbc.270.50.30093",
language = "English (US)",
volume = "270",
pages = "30093--30101",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "50",

}

TY - JOUR

T1 - Delayed mammary tumor progression in Muc-1 null mice

AU - Spicer, Andrew P.

AU - Rowse, Gerald J.

AU - Lidner, Thomas K.

AU - Gendler, Sandra J

PY - 1995/12/15

Y1 - 1995/12/15

N2 - The mucin gene, Muc-1, encodes a high molecular weight integral membrane glycoprotein that is present on the apical surface of most simple secretory epithelial cells. Muc-1 is highly expressed and aberrantly glycosylated by most carcinomas and metastatic lesions. Numerous functions have been proposed for this molecule, including protection of the epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor progression. Mice deficient in Muc-1 were generated using homologous recombination in embryonic stem cells. These mice appeared to develop normally and were healthy and fertile. However, the growth rate of primary breast tumors induced by polyoma middle T antigen was found to be significantly slower in Muc-1 deficient mice. This suggests that Muc-1 plays an important role in the progression of mammary carcinoma.

AB - The mucin gene, Muc-1, encodes a high molecular weight integral membrane glycoprotein that is present on the apical surface of most simple secretory epithelial cells. Muc-1 is highly expressed and aberrantly glycosylated by most carcinomas and metastatic lesions. Numerous functions have been proposed for this molecule, including protection of the epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor progression. Mice deficient in Muc-1 were generated using homologous recombination in embryonic stem cells. These mice appeared to develop normally and were healthy and fertile. However, the growth rate of primary breast tumors induced by polyoma middle T antigen was found to be significantly slower in Muc-1 deficient mice. This suggests that Muc-1 plays an important role in the progression of mammary carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0029589586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029589586&partnerID=8YFLogxK

U2 - 10.1074/jbc.270.50.30093

DO - 10.1074/jbc.270.50.30093

M3 - Article

C2 - 8530414

AN - SCOPUS:0029589586

VL - 270

SP - 30093

EP - 30101

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 50

ER -