Delayed leukoencephalopathy in survivors with small cell lung cancer

N. K. So, Brian Patrick O'Neill, S. Frytak, R. T. Eagan, F. Earnest IV, R. E. Lee

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Six patients with small cell lung cancer developed a slowly progressive neurologic syndrome characterized by apathy, abulia, memory loss, gait ataxia, and corticospinal tract signs 26 to 50 months (mean, 35.2 months) after prophylactic cranial irradiation and systemic chemotherapy. In each case this was accompanied by CT and/or MRI evidence of changes in the periventricular white matter. These patients are long-term survivors (41 to 69 months) and do not have CNS metastases.

Original languageEnglish (US)
Pages (from-to)1198-1201
Number of pages4
JournalNeurology
Volume37
Issue number7
StatePublished - 1987

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Leukoencephalopathies
Small Cell Lung Carcinoma
Survivors
Gait Ataxia
Cranial Irradiation
Apathy
Pyramidal Tracts
Memory Disorders
Nervous System
Neoplasm Metastasis
Drug Therapy
White Matter

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

So, N. K., O'Neill, B. P., Frytak, S., Eagan, R. T., Earnest IV, F., & Lee, R. E. (1987). Delayed leukoencephalopathy in survivors with small cell lung cancer. Neurology, 37(7), 1198-1201.

Delayed leukoencephalopathy in survivors with small cell lung cancer. / So, N. K.; O'Neill, Brian Patrick; Frytak, S.; Eagan, R. T.; Earnest IV, F.; Lee, R. E.

In: Neurology, Vol. 37, No. 7, 1987, p. 1198-1201.

Research output: Contribution to journalArticle

So, NK, O'Neill, BP, Frytak, S, Eagan, RT, Earnest IV, F & Lee, RE 1987, 'Delayed leukoencephalopathy in survivors with small cell lung cancer', Neurology, vol. 37, no. 7, pp. 1198-1201.
So NK, O'Neill BP, Frytak S, Eagan RT, Earnest IV F, Lee RE. Delayed leukoencephalopathy in survivors with small cell lung cancer. Neurology. 1987;37(7):1198-1201.
So, N. K. ; O'Neill, Brian Patrick ; Frytak, S. ; Eagan, R. T. ; Earnest IV, F. ; Lee, R. E. / Delayed leukoencephalopathy in survivors with small cell lung cancer. In: Neurology. 1987 ; Vol. 37, No. 7. pp. 1198-1201.
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