Delayed leuko-encephalopathy in survivors with small cell lung cancer

N. K. So; B. P. O’Neill; S. Frytak; R. T. Eagan; F. Earnest; R. E. Lee

doi:10.1212/wnl.37.7.1198

Delayed leuko-encephalopathy in survivors with small cell lung cancer

N. K. So, B. P. O’Neill, S. Frytak, R. T. Eagan, F. Earnest, R. E. Lee

Neurology

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Abstract

Six patients with small cell lung cancer developed a. slowly progressive neurologic syndrome characterized by apathy, abulia, memory loss, gait ataxia, and corticospinal tract signs 26 to 50 months (mean, 35.2 months) after prophylactic cranial irradiation and systemic chemotherapy. In each case this was accompanied by CT and/or MRI evidence of changes in the peri-ventricular white matter. These patients are long-term survivors (41 to 69 months) and do not have CNS metastases.

Original language	English (US)
Pages (from-to)	1198-1201
Number of pages	4
Journal	Neurology
Volume	37
Issue number	7
DOIs	https://doi.org/10.1212/wnl.37.7.1198
State	Published - Jul 1987

ASJC Scopus subject areas

Clinical Neurology

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title = "Delayed leuko-encephalopathy in survivors with small cell lung cancer",

abstract = "Six patients with small cell lung cancer developed a. slowly progressive neurologic syndrome characterized by apathy, abulia, memory loss, gait ataxia, and corticospinal tract signs 26 to 50 months (mean, 35.2 months) after prophylactic cranial irradiation and systemic chemotherapy. In each case this was accompanied by CT and/or MRI evidence of changes in the peri-ventricular white matter. These patients are long-term survivors (41 to 69 months) and do not have CNS metastases.",

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AU - So, N. K.

AU - O’Neill, B. P.

AU - Frytak, S.

AU - Eagan, R. T.

AU - Earnest, F.

AU - Lee, R. E.

PY - 1987/7

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N2 - Six patients with small cell lung cancer developed a. slowly progressive neurologic syndrome characterized by apathy, abulia, memory loss, gait ataxia, and corticospinal tract signs 26 to 50 months (mean, 35.2 months) after prophylactic cranial irradiation and systemic chemotherapy. In each case this was accompanied by CT and/or MRI evidence of changes in the peri-ventricular white matter. These patients are long-term survivors (41 to 69 months) and do not have CNS metastases.

AB - Six patients with small cell lung cancer developed a. slowly progressive neurologic syndrome characterized by apathy, abulia, memory loss, gait ataxia, and corticospinal tract signs 26 to 50 months (mean, 35.2 months) after prophylactic cranial irradiation and systemic chemotherapy. In each case this was accompanied by CT and/or MRI evidence of changes in the peri-ventricular white matter. These patients are long-term survivors (41 to 69 months) and do not have CNS metastases.

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Delayed leuko-encephalopathy in survivors with small cell lung cancer

Abstract

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