Delayed hemolysis resulting from anti-A1 after liver transplantation

M. E. Brecher, S. B. Moore, R. K. Reisner, Jorge Rakela, R. A F Krom

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The authors report a case of a delayed hemolytic transfusion reaction in a type A2 recipient of a type O liver allograft. An anti-A1 antibody reactive at 37°C in the indirect antiglobulin test was identified both in the patient's serum and in an eluate. Hemolysis secondary to the production of anti-A1 has been reported to be extremely rare. The English-language literature has six cases before 1979. During the 1980s, an additional seven cases were reported; six involved transplantation of a solid organ, and in each such case the donor was type O and the recipient was type A1 or A2. Recommendations regarding transfusion practice in such cases are made. An association among the transplantation of a type O organ to a type A recipient, the use of cyclosporine, and an apparent increase in the occurrence of clinically significant anti-A1 is suggested.

Original languageEnglish (US)
Pages (from-to)232-235
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume91
Issue number2
StatePublished - 1989

Fingerprint

Hemolysis
varespladib methyl
Liver Transplantation
Transplantation
Coombs Test
Cyclosporine
Allografts
Anti-Idiotypic Antibodies
Language
Tissue Donors
Liver
Serum
Transfusion Reaction

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Brecher, M. E., Moore, S. B., Reisner, R. K., Rakela, J., & Krom, R. A. F. (1989). Delayed hemolysis resulting from anti-A1 after liver transplantation. American Journal of Clinical Pathology, 91(2), 232-235.

Delayed hemolysis resulting from anti-A1 after liver transplantation. / Brecher, M. E.; Moore, S. B.; Reisner, R. K.; Rakela, Jorge; Krom, R. A F.

In: American Journal of Clinical Pathology, Vol. 91, No. 2, 1989, p. 232-235.

Research output: Contribution to journalArticle

Brecher, ME, Moore, SB, Reisner, RK, Rakela, J & Krom, RAF 1989, 'Delayed hemolysis resulting from anti-A1 after liver transplantation', American Journal of Clinical Pathology, vol. 91, no. 2, pp. 232-235.
Brecher, M. E. ; Moore, S. B. ; Reisner, R. K. ; Rakela, Jorge ; Krom, R. A F. / Delayed hemolysis resulting from anti-A1 after liver transplantation. In: American Journal of Clinical Pathology. 1989 ; Vol. 91, No. 2. pp. 232-235.
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