Delayed hemolysis resulting from anti-A1 after liver transplantation

M. E. Brecher, S. B. Moore, R. K. Reisner, J. Rakela, R. A.F. Krom

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Abstract

The authors report a case of a delayed hemolytic transfusion reaction in a type A2 recipient of a type O liver allograft. An anti-A1 antibody reactive at 37°C in the indirect antiglobulin test was identified both in the patient's serum and in an eluate. Hemolysis secondary to the production of anti-A1 has been reported to be extremely rare. The English-language literature has six cases before 1979. During the 1980s, an additional seven cases were reported; six involved transplantation of a solid organ, and in each such case the donor was type O and the recipient was type A1 or A2. Recommendations regarding transfusion practice in such cases are made. An association among the transplantation of a type O organ to a type A recipient, the use of cyclosporine, and an apparent increase in the occurrence of clinically significant anti-A1 is suggested.

Original languageEnglish (US)
Pages (from-to)232-235
Number of pages4
JournalAmerican journal of clinical pathology
Volume91
Issue number2
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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