Dehydroepiandrosterone

Is there a role for replacement?

Ketan K. Dhatariya, K Sreekumaran Nair

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Dehydroepiandrosterone (DHEA) and its sulfated ester are found in high concentrations in the plasma; however, their role in normal human physiology, other than as precursors for sex hormones, remains incompletely defined. Studies of rodent models have shown that these hormones have beneficial effects on a wide variety of conditions, such as diabetes, obesity, immune function, atherosclerosis, and many of the disorders associated with normal aging. However, rodents are not the best models to study the actions of these hormones because they have very little endogenous DHEA; thus, the doses given to these animals are usually suprapharmacological. Human studies have been performed to determine the potential beneficial effects of DHEA replacement in persons with low DHEA levels. Results have been conflicting. Human studies suggest a potential role for DHEA replacement in persons who have undergone adrenalectomy and possibly in the aging population. However, long-term studies assessing the benefits vs adverse effects must be done before DHEA replacement can be recommended.

Original languageEnglish (US)
Pages (from-to)1257-1273
Number of pages17
JournalMayo Clinic Proceedings
Volume78
Issue number10
StatePublished - Oct 1 2003

Fingerprint

Dehydroepiandrosterone
Rodentia
Hormones
Adrenalectomy
Gonadal Steroid Hormones
Atherosclerosis
Esters
Obesity
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dehydroepiandrosterone : Is there a role for replacement? / Dhatariya, Ketan K.; Nair, K Sreekumaran.

In: Mayo Clinic Proceedings, Vol. 78, No. 10, 01.10.2003, p. 1257-1273.

Research output: Contribution to journalArticle

Dhatariya, Ketan K. ; Nair, K Sreekumaran. / Dehydroepiandrosterone : Is there a role for replacement?. In: Mayo Clinic Proceedings. 2003 ; Vol. 78, No. 10. pp. 1257-1273.
@article{9f13684e7ed642e59dfb7c23ef1c6f8a,
title = "Dehydroepiandrosterone: Is there a role for replacement?",
abstract = "Dehydroepiandrosterone (DHEA) and its sulfated ester are found in high concentrations in the plasma; however, their role in normal human physiology, other than as precursors for sex hormones, remains incompletely defined. Studies of rodent models have shown that these hormones have beneficial effects on a wide variety of conditions, such as diabetes, obesity, immune function, atherosclerosis, and many of the disorders associated with normal aging. However, rodents are not the best models to study the actions of these hormones because they have very little endogenous DHEA; thus, the doses given to these animals are usually suprapharmacological. Human studies have been performed to determine the potential beneficial effects of DHEA replacement in persons with low DHEA levels. Results have been conflicting. Human studies suggest a potential role for DHEA replacement in persons who have undergone adrenalectomy and possibly in the aging population. However, long-term studies assessing the benefits vs adverse effects must be done before DHEA replacement can be recommended.",
author = "Dhatariya, {Ketan K.} and Nair, {K Sreekumaran}",
year = "2003",
month = "10",
day = "1",
language = "English (US)",
volume = "78",
pages = "1257--1273",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "10",

}

TY - JOUR

T1 - Dehydroepiandrosterone

T2 - Is there a role for replacement?

AU - Dhatariya, Ketan K.

AU - Nair, K Sreekumaran

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Dehydroepiandrosterone (DHEA) and its sulfated ester are found in high concentrations in the plasma; however, their role in normal human physiology, other than as precursors for sex hormones, remains incompletely defined. Studies of rodent models have shown that these hormones have beneficial effects on a wide variety of conditions, such as diabetes, obesity, immune function, atherosclerosis, and many of the disorders associated with normal aging. However, rodents are not the best models to study the actions of these hormones because they have very little endogenous DHEA; thus, the doses given to these animals are usually suprapharmacological. Human studies have been performed to determine the potential beneficial effects of DHEA replacement in persons with low DHEA levels. Results have been conflicting. Human studies suggest a potential role for DHEA replacement in persons who have undergone adrenalectomy and possibly in the aging population. However, long-term studies assessing the benefits vs adverse effects must be done before DHEA replacement can be recommended.

AB - Dehydroepiandrosterone (DHEA) and its sulfated ester are found in high concentrations in the plasma; however, their role in normal human physiology, other than as precursors for sex hormones, remains incompletely defined. Studies of rodent models have shown that these hormones have beneficial effects on a wide variety of conditions, such as diabetes, obesity, immune function, atherosclerosis, and many of the disorders associated with normal aging. However, rodents are not the best models to study the actions of these hormones because they have very little endogenous DHEA; thus, the doses given to these animals are usually suprapharmacological. Human studies have been performed to determine the potential beneficial effects of DHEA replacement in persons with low DHEA levels. Results have been conflicting. Human studies suggest a potential role for DHEA replacement in persons who have undergone adrenalectomy and possibly in the aging population. However, long-term studies assessing the benefits vs adverse effects must be done before DHEA replacement can be recommended.

UR - http://www.scopus.com/inward/record.url?scp=0141593580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141593580&partnerID=8YFLogxK

M3 - Article

VL - 78

SP - 1257

EP - 1273

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 10

ER -