Degeneration of brainstem respiratory neurons in dementia with Lewy bodies

Michael F. Presti, Ann M. Schmeichel, Phillip Anson Low, Joseph E Parisi, Eduardo E. Benarroch

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Respiratory dysfunction, including sleep disordered breathing, is characteristic of multiple system atrophy (MSA) and may reflect degeneration of brainstem respiratory nuclei involved in respiratory rhythmogenesis and chemosensitivity, including the pre-Bötzinger complex (preBötC), nucleus raphe pallidus (RPa), and nucleus raphe obscurus (ROb). However, impaired ventilatory responses to hypercapnia have also been reported in dementia with Lewy bodies (DLB), suggesting that these nuclei may also be affected in DLB. Objectives: To determine whether there is involvement of the preBötC, RPa, and ROb in DLB. Design: We applied stereological methods to analyze sections immunostained for neurokinin-1 receptor and tryptophan hydroxylase in neuropathologically confirmed cases of DLB, MSA, and controls. Results: Reduction of neuronal density occurred in all three nuclei in DLB, as well as in MSA. The magnitude of neuronal depletion in ROb was similar in DLB and MSA (49% versus 56% respectively, compared to controls, P < 0.05), but neuronal loss in the preBötC and RPa was less severe in DLB than in MSA (40% loss in preBötC of DLB, P < 0.05 and 68% loss in MSA, P < 0.0001, compared to controls; 46% loss in RPa of DLB, P < 0.05 and 73% loss in MSA P < 0.0001, compared to controls). Conclusions: Medullary respiratory nuclei are affected in dementia with Lewy bodies but less severely than in multiple system atrophy. This may help explain differences in the frequency of sleep disordered breathing in these two disorders.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalSleep
Volume37
Issue number2
DOIs
StatePublished - Feb 1 2014

Fingerprint

Lewy Body Disease
Multiple System Atrophy
Brain Stem
Neurons
Sleep Apnea Syndromes
Tryptophan Hydroxylase
Neurokinin-1 Receptors
Raphe Nuclei
Hypercapnia

Keywords

  • DLB
  • Medullary raphe
  • MSA
  • Pre-Bötzinger
  • Respiration

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Presti, M. F., Schmeichel, A. M., Low, P. A., Parisi, J. E., & Benarroch, E. E. (2014). Degeneration of brainstem respiratory neurons in dementia with Lewy bodies. Sleep, 37(2), 373-378. https://doi.org/10.5665/sleep.3418

Degeneration of brainstem respiratory neurons in dementia with Lewy bodies. / Presti, Michael F.; Schmeichel, Ann M.; Low, Phillip Anson; Parisi, Joseph E; Benarroch, Eduardo E.

In: Sleep, Vol. 37, No. 2, 01.02.2014, p. 373-378.

Research output: Contribution to journalArticle

Presti, MF, Schmeichel, AM, Low, PA, Parisi, JE & Benarroch, EE 2014, 'Degeneration of brainstem respiratory neurons in dementia with Lewy bodies', Sleep, vol. 37, no. 2, pp. 373-378. https://doi.org/10.5665/sleep.3418
Presti MF, Schmeichel AM, Low PA, Parisi JE, Benarroch EE. Degeneration of brainstem respiratory neurons in dementia with Lewy bodies. Sleep. 2014 Feb 1;37(2):373-378. https://doi.org/10.5665/sleep.3418
Presti, Michael F. ; Schmeichel, Ann M. ; Low, Phillip Anson ; Parisi, Joseph E ; Benarroch, Eduardo E. / Degeneration of brainstem respiratory neurons in dementia with Lewy bodies. In: Sleep. 2014 ; Vol. 37, No. 2. pp. 373-378.
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abstract = "Background: Respiratory dysfunction, including sleep disordered breathing, is characteristic of multiple system atrophy (MSA) and may reflect degeneration of brainstem respiratory nuclei involved in respiratory rhythmogenesis and chemosensitivity, including the pre-B{\"o}tzinger complex (preB{\"o}tC), nucleus raphe pallidus (RPa), and nucleus raphe obscurus (ROb). However, impaired ventilatory responses to hypercapnia have also been reported in dementia with Lewy bodies (DLB), suggesting that these nuclei may also be affected in DLB. Objectives: To determine whether there is involvement of the preB{\"o}tC, RPa, and ROb in DLB. Design: We applied stereological methods to analyze sections immunostained for neurokinin-1 receptor and tryptophan hydroxylase in neuropathologically confirmed cases of DLB, MSA, and controls. Results: Reduction of neuronal density occurred in all three nuclei in DLB, as well as in MSA. The magnitude of neuronal depletion in ROb was similar in DLB and MSA (49{\%} versus 56{\%} respectively, compared to controls, P < 0.05), but neuronal loss in the preB{\"o}tC and RPa was less severe in DLB than in MSA (40{\%} loss in preB{\"o}tC of DLB, P < 0.05 and 68{\%} loss in MSA, P < 0.0001, compared to controls; 46{\%} loss in RPa of DLB, P < 0.05 and 73{\%} loss in MSA P < 0.0001, compared to controls). Conclusions: Medullary respiratory nuclei are affected in dementia with Lewy bodies but less severely than in multiple system atrophy. This may help explain differences in the frequency of sleep disordered breathing in these two disorders.",
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