Deformable registration of radiation isodose lines to delayed contrast-enhanced magnetic resonance images for assessment of myocardial lesion formation following proton beam therapy

M. E. Rettmann, A. Suzuki, A. J. Deisher, S. Wang, S. Hohmann, H. Konishi, H. I. Lehmann, J. J. Kruse, J. T. Cusma, L. K. Newman, K. D. Parker, M. G. Herman, D. L. Packer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Ventricular tachycardia is increasingly treated with ablation therapy, a technique in which catheters are guided into the ventricle and radiofrequency energy is delivered into the myocardial tissue to interrupt arrhythmic electrical pathways. Recent efforts have investigated the use of noninvasive external beam therapy for treatment of ventricular tachycardia where target regions are identified in the myocardium and treated using external beams. The relationship between the planned dose map and myocardial tissue change, however, has not yet been quantified. In this work, we use a deformable registration algorithm to align dose maps planned from baseline computed-Tomography scans to delayed contrast-enhanced magnetic resonance imaging scans taken at 4 week intervals following proton beam therapy. From this data, the relationship between the planned dose and image enhancement, which serves as a surrogate for tissue change, can be quantified.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2018
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Robert J. Webster
PublisherSPIE
ISBN (Electronic)9781510616417
DOIs
StatePublished - Jan 1 2018
EventMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling - Houston, United States
Duration: Feb 12 2018Feb 15 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10576
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling
CountryUnited States
CityHouston
Period2/12/182/15/18

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Rettmann, M. E., Suzuki, A., Deisher, A. J., Wang, S., Hohmann, S., Konishi, H., Lehmann, H. I., Kruse, J. J., Cusma, J. T., Newman, L. K., Parker, K. D., Herman, M. G., & Packer, D. L. (2018). Deformable registration of radiation isodose lines to delayed contrast-enhanced magnetic resonance images for assessment of myocardial lesion formation following proton beam therapy. In B. Fei, & R. J. Webster (Eds.), Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling [105760G] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10576). SPIE. https://doi.org/10.1117/12.2295439