Defining the optimal dose of stereotactic radiosurgery for treating cerebral metastases in elderly patients

Dirk Rades, Markus Dahlke, Liesa Dziggel, Stefan Janssen, Amira Bajrovic, Ngo Thuy Trang, Mai Trong Khoa, Steven E. Schild

Research output: Contribution to journalArticle

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Abstract

Background/Aim: In oncology, elderly people are a separate group of patients requiring special consideration. This applies to the treatment of cerebral metastases as well. The present study focused on elderly patients receiving stereotactic radiosurgery (SRS) for few cerebral lesions. Patients and Methods: In 95 patients aged ≥65 years, two SRS doses, 16-18 Gy (n=44) and 20 Gy (n=51), were compared regarding outcomes of SRS. Results: The overall intracerebral control rates at 12 months were 30% after 16- 18 Gy and 45% after 20 Gy (p=0.53). Twelve-month rates of freedom from new intracerebral lesions were 41% and 52%, respectively (p=0.63). Twelve-month local control rates of the irradiated lesions were 55% and 81%, respectively (p=0.069). Overall survival rates at 12 months were 29% and 31%, respectively (p=0.67). Conclusion: SRS with 16- 18 Gy was not significantly inferior to SRS with 20 Gy in elderly patients with few cerebral metastases.

Original languageEnglish (US)
Pages (from-to)5701-5704
Number of pages4
JournalAnticancer Research
Volume35
Issue number10
StatePublished - Oct 1 2015

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Radiosurgery
Neoplasm Metastasis
Survival Rate

Keywords

  • Cerebral metastases
  • Elderly patients
  • Optimal dose
  • Stereotactic radiosurgery
  • Treatment results

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rades, D., Dahlke, M., Dziggel, L., Janssen, S., Bajrovic, A., Trang, N. T., ... Schild, S. E. (2015). Defining the optimal dose of stereotactic radiosurgery for treating cerebral metastases in elderly patients. Anticancer Research, 35(10), 5701-5704.

Defining the optimal dose of stereotactic radiosurgery for treating cerebral metastases in elderly patients. / Rades, Dirk; Dahlke, Markus; Dziggel, Liesa; Janssen, Stefan; Bajrovic, Amira; Trang, Ngo Thuy; Khoa, Mai Trong; Schild, Steven E.

In: Anticancer Research, Vol. 35, No. 10, 01.10.2015, p. 5701-5704.

Research output: Contribution to journalArticle

Rades, D, Dahlke, M, Dziggel, L, Janssen, S, Bajrovic, A, Trang, NT, Khoa, MT & Schild, SE 2015, 'Defining the optimal dose of stereotactic radiosurgery for treating cerebral metastases in elderly patients', Anticancer Research, vol. 35, no. 10, pp. 5701-5704.
Rades D, Dahlke M, Dziggel L, Janssen S, Bajrovic A, Trang NT et al. Defining the optimal dose of stereotactic radiosurgery for treating cerebral metastases in elderly patients. Anticancer Research. 2015 Oct 1;35(10):5701-5704.
Rades, Dirk ; Dahlke, Markus ; Dziggel, Liesa ; Janssen, Stefan ; Bajrovic, Amira ; Trang, Ngo Thuy ; Khoa, Mai Trong ; Schild, Steven E. / Defining the optimal dose of stereotactic radiosurgery for treating cerebral metastases in elderly patients. In: Anticancer Research. 2015 ; Vol. 35, No. 10. pp. 5701-5704.
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