Defining the limitations of transcutaneous bilirubin measurement in late preterm newborns

K. L. Fine, W. A. Carey, J. A W Schuster, S. C. Bryant, W. J. Cook, B. S. Karon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective:The objective of this study is to determine the impact of postnatal age on the bias between transcutaneous (TcB) and total serum bilirubin (TSB), and evaluate a TcB screening protocol.Study Design:Preterm and term infants had paired TcB and TSB performed on days 1 to 3 of life; a subset of preterm infants had measurements on days 4 to 7. Sensitivity and specificity of TcB (plotted on an age-specific TSB nomogram) for prediction of high-intermediate (HIR) or high-risk TSB were calculated.Results:Median TcB bias was 2.6 and 2.5 mg dl-1 for term and preterm infants in the first 3 days of life, respectively. However, median bias was 2.2 mg dl-1 for preterm infants at 4 to 7 days of life. TcB in preterm infants predicted HIR or high-risk TSB with 94% sensitivity and 56% specificity.Conclusion:TcB screening protocols developed for term infants can be used for late preterm infants in the first 3 days of life.Journal of Perinatology advance online publication, 16 February 2017; doi:10.1038/jp.2017.8.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Feb 16 2017

Fingerprint

Bilirubin
Premature Infants
Newborn Infant
Serum
Perinatology
Sensitivity and Specificity
Nomograms
Publications

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Fine, K. L., Carey, W. A., Schuster, J. A. W., Bryant, S. C., Cook, W. J., & Karon, B. S. (Accepted/In press). Defining the limitations of transcutaneous bilirubin measurement in late preterm newborns. Journal of Perinatology. https://doi.org/10.1038/jp.2017.8

Defining the limitations of transcutaneous bilirubin measurement in late preterm newborns. / Fine, K. L.; Carey, W. A.; Schuster, J. A W; Bryant, S. C.; Cook, W. J.; Karon, B. S.

In: Journal of Perinatology, 16.02.2017.

Research output: Contribution to journalArticle

Fine, K. L. ; Carey, W. A. ; Schuster, J. A W ; Bryant, S. C. ; Cook, W. J. ; Karon, B. S. / Defining the limitations of transcutaneous bilirubin measurement in late preterm newborns. In: Journal of Perinatology. 2017.
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