Defining the limitations of transcutaneous bilirubin measurement in late preterm newborns

K. L. Fine, W. A. Carey, J. A W Schuster, S. C. Bryant, W. J. Cook, B. S. Karon

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective:The objective of this study is to determine the impact of postnatal age on the bias between transcutaneous (TcB) and total serum bilirubin (TSB), and evaluate a TcB screening protocol.Study Design:Preterm and term infants had paired TcB and TSB performed on days 1 to 3 of life; a subset of preterm infants had measurements on days 4 to 7. Sensitivity and specificity of TcB (plotted on an age-specific TSB nomogram) for prediction of high-intermediate (HIR) or high-risk TSB were calculated.Results:Median TcB bias was 2.6 and 2.5 mg dl-1 for term and preterm infants in the first 3 days of life, respectively. However, median bias was 2.2 mg dl-1 for preterm infants at 4 to 7 days of life. TcB in preterm infants predicted HIR or high-risk TSB with 94% sensitivity and 56% specificity.Conclusion:TcB screening protocols developed for term infants can be used for late preterm infants in the first 3 days of life.Journal of Perinatology advance online publication, 16 February 2017; doi:10.1038/jp.2017.8.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Feb 16 2017

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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