Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients

Dirk Rades, Lukas J A Stalpers, Rainer Schulte, Theo Veninga, Hiba Basic, Rita Engenhart-Cabilic, Steven E. Schild, Peter J. Hoskin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Many different schedules are used world wide for radiotherapy (RT) of metastatic spinal cord compression (MSCC). Non-small cell lung cancer (NSCLC) patients have an extraordinarily poor survival prognosis and would benefit from a short overall treatment time. This retrospective study compares short-course RT (1 × 8 Gy/1 day, 5 × 4 Gy/1 week) and long-course RT (10 × 3 Gy/2 weeks, 15 × 2.5 Gy/3 weeks, 20 × 2 Gy/4 weeks) for functional outcome in 252 NSCLC patients developing MSCC. Improvement of motor function occurred in 14% of patients, no change in 54%, and deterioration in 32%. Functional outcome was affected by the time of developing motor deficits before RT (>14 days better than 1-7 days and 8-14 days, P < 0.001), not by the radiation regimen (P = 0.87). In the short-course RT group, functional outcome was similar for 1 × 8 Gy and 5 × 4 Gy (P = 0.94). Short-course and long-course RT appear similarly effective for MSCC in NSCLC patients. As 1 × 8 Gy and 5 × 4 Gy showed comparable results, 1 × 8 Gy can be considered appropriate.

Original languageEnglish (US)
Pages (from-to)1052-1056
Number of pages5
JournalEuropean Journal of Cancer
Volume42
Issue number8
DOIs
StatePublished - May 2006

Fingerprint

Spinal Cord Compression
Non-Small Cell Lung Carcinoma
Radiotherapy
Appointments and Schedules
Retrospective Studies
Radiation
Survival

Keywords

  • Metastatic spinal cord compression
  • Non-small cell lung cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Rades, D., Stalpers, L. J. A., Schulte, R., Veninga, T., Basic, H., Engenhart-Cabilic, R., ... Hoskin, P. J. (2006). Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients. European Journal of Cancer, 42(8), 1052-1056. https://doi.org/10.1016/j.ejca.2005.12.022

Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients. / Rades, Dirk; Stalpers, Lukas J A; Schulte, Rainer; Veninga, Theo; Basic, Hiba; Engenhart-Cabilic, Rita; Schild, Steven E.; Hoskin, Peter J.

In: European Journal of Cancer, Vol. 42, No. 8, 05.2006, p. 1052-1056.

Research output: Contribution to journalArticle

Rades, D, Stalpers, LJA, Schulte, R, Veninga, T, Basic, H, Engenhart-Cabilic, R, Schild, SE & Hoskin, PJ 2006, 'Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients', European Journal of Cancer, vol. 42, no. 8, pp. 1052-1056. https://doi.org/10.1016/j.ejca.2005.12.022
Rades, Dirk ; Stalpers, Lukas J A ; Schulte, Rainer ; Veninga, Theo ; Basic, Hiba ; Engenhart-Cabilic, Rita ; Schild, Steven E. ; Hoskin, Peter J. / Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients. In: European Journal of Cancer. 2006 ; Vol. 42, No. 8. pp. 1052-1056.
@article{c007b6664c85427882e03eb1d6925d19,
title = "Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients",
abstract = "Many different schedules are used world wide for radiotherapy (RT) of metastatic spinal cord compression (MSCC). Non-small cell lung cancer (NSCLC) patients have an extraordinarily poor survival prognosis and would benefit from a short overall treatment time. This retrospective study compares short-course RT (1 × 8 Gy/1 day, 5 × 4 Gy/1 week) and long-course RT (10 × 3 Gy/2 weeks, 15 × 2.5 Gy/3 weeks, 20 × 2 Gy/4 weeks) for functional outcome in 252 NSCLC patients developing MSCC. Improvement of motor function occurred in 14{\%} of patients, no change in 54{\%}, and deterioration in 32{\%}. Functional outcome was affected by the time of developing motor deficits before RT (>14 days better than 1-7 days and 8-14 days, P < 0.001), not by the radiation regimen (P = 0.87). In the short-course RT group, functional outcome was similar for 1 × 8 Gy and 5 × 4 Gy (P = 0.94). Short-course and long-course RT appear similarly effective for MSCC in NSCLC patients. As 1 × 8 Gy and 5 × 4 Gy showed comparable results, 1 × 8 Gy can be considered appropriate.",
keywords = "Metastatic spinal cord compression, Non-small cell lung cancer, Radiotherapy",
author = "Dirk Rades and Stalpers, {Lukas J A} and Rainer Schulte and Theo Veninga and Hiba Basic and Rita Engenhart-Cabilic and Schild, {Steven E.} and Hoskin, {Peter J.}",
year = "2006",
month = "5",
doi = "10.1016/j.ejca.2005.12.022",
language = "English (US)",
volume = "42",
pages = "1052--1056",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients

AU - Rades, Dirk

AU - Stalpers, Lukas J A

AU - Schulte, Rainer

AU - Veninga, Theo

AU - Basic, Hiba

AU - Engenhart-Cabilic, Rita

AU - Schild, Steven E.

AU - Hoskin, Peter J.

PY - 2006/5

Y1 - 2006/5

N2 - Many different schedules are used world wide for radiotherapy (RT) of metastatic spinal cord compression (MSCC). Non-small cell lung cancer (NSCLC) patients have an extraordinarily poor survival prognosis and would benefit from a short overall treatment time. This retrospective study compares short-course RT (1 × 8 Gy/1 day, 5 × 4 Gy/1 week) and long-course RT (10 × 3 Gy/2 weeks, 15 × 2.5 Gy/3 weeks, 20 × 2 Gy/4 weeks) for functional outcome in 252 NSCLC patients developing MSCC. Improvement of motor function occurred in 14% of patients, no change in 54%, and deterioration in 32%. Functional outcome was affected by the time of developing motor deficits before RT (>14 days better than 1-7 days and 8-14 days, P < 0.001), not by the radiation regimen (P = 0.87). In the short-course RT group, functional outcome was similar for 1 × 8 Gy and 5 × 4 Gy (P = 0.94). Short-course and long-course RT appear similarly effective for MSCC in NSCLC patients. As 1 × 8 Gy and 5 × 4 Gy showed comparable results, 1 × 8 Gy can be considered appropriate.

AB - Many different schedules are used world wide for radiotherapy (RT) of metastatic spinal cord compression (MSCC). Non-small cell lung cancer (NSCLC) patients have an extraordinarily poor survival prognosis and would benefit from a short overall treatment time. This retrospective study compares short-course RT (1 × 8 Gy/1 day, 5 × 4 Gy/1 week) and long-course RT (10 × 3 Gy/2 weeks, 15 × 2.5 Gy/3 weeks, 20 × 2 Gy/4 weeks) for functional outcome in 252 NSCLC patients developing MSCC. Improvement of motor function occurred in 14% of patients, no change in 54%, and deterioration in 32%. Functional outcome was affected by the time of developing motor deficits before RT (>14 days better than 1-7 days and 8-14 days, P < 0.001), not by the radiation regimen (P = 0.87). In the short-course RT group, functional outcome was similar for 1 × 8 Gy and 5 × 4 Gy (P = 0.94). Short-course and long-course RT appear similarly effective for MSCC in NSCLC patients. As 1 × 8 Gy and 5 × 4 Gy showed comparable results, 1 × 8 Gy can be considered appropriate.

KW - Metastatic spinal cord compression

KW - Non-small cell lung cancer

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=33646406281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646406281&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2005.12.022

DO - 10.1016/j.ejca.2005.12.022

M3 - Article

VL - 42

SP - 1052

EP - 1056

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 8

ER -