Defining mild cognitive impairment in Parkinson's disease

John Nathaniel Caviness, Erika M Driver-Dunckley, Donald J. Connor, Marwan N. Sabbagh, Joseph G. Hentz, Brie Noble, Virgilio Gerald H Evidente, Holly A. Shill, Charles Howard Adler

Research output: Contribution to journalArticle

326 Citations (Scopus)

Abstract

Our purpose was to characterize a state of mild cognitive impairment (MCI) in Parkinson's disease (PD) (PD-MCI) that would be analogous to the MCI that is posited as a precursor of Alzheimer's disease (AD). We categorized 86 PD subjects in a brain bank population as either cognitively normal (PD-CogNL), PD-MCI using criteria that included a 1.5 standard deviation or greater deficit upon neuropsychological testing consistently across at least one cognitive domain without dementia, and PD dementia (PD-D) using DSM-IV criteria. Twenty-one percent of our PD sample met criteria for PD-MCI, 62% were PD-CogNL, and 17% had PD-D. The mean duration of PD and MMSE scores of the PD-MCI group were intermediate and significantly different from both PD-CogNL and PD-D. The cognitive domain most frequently abnormal in PD-MCI was frontal/executive dysfunction followed by amnestic deficit. Single domain PD-MCI was more common than PD-MCI involving multiple domains. We conclude that a stage of clinical cognitive impairment in PD exists between PD-CogNL and PD-D, and it may be defined by applying criteria similar to the MCI that is posited as a precursor of AD. Defining PD-MCI offers an opportunity for further study of cognitive impairment in PD and targets for earlier therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1272-1277
Number of pages6
JournalMovement Disorders
Volume22
Issue number9
DOIs
StatePublished - Jul 15 2007

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Parkinson Disease
Cognitive Dysfunction
Dementia
Alzheimer Disease

Keywords

  • Dementia
  • Mild cognitive impairment
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Defining mild cognitive impairment in Parkinson's disease. / Caviness, John Nathaniel; Driver-Dunckley, Erika M; Connor, Donald J.; Sabbagh, Marwan N.; Hentz, Joseph G.; Noble, Brie; Evidente, Virgilio Gerald H; Shill, Holly A.; Adler, Charles Howard.

In: Movement Disorders, Vol. 22, No. 9, 15.07.2007, p. 1272-1277.

Research output: Contribution to journalArticle

Caviness, JN, Driver-Dunckley, EM, Connor, DJ, Sabbagh, MN, Hentz, JG, Noble, B, Evidente, VGH, Shill, HA & Adler, CH 2007, 'Defining mild cognitive impairment in Parkinson's disease', Movement Disorders, vol. 22, no. 9, pp. 1272-1277. https://doi.org/10.1002/mds.21453
Caviness, John Nathaniel ; Driver-Dunckley, Erika M ; Connor, Donald J. ; Sabbagh, Marwan N. ; Hentz, Joseph G. ; Noble, Brie ; Evidente, Virgilio Gerald H ; Shill, Holly A. ; Adler, Charles Howard. / Defining mild cognitive impairment in Parkinson's disease. In: Movement Disorders. 2007 ; Vol. 22, No. 9. pp. 1272-1277.
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