Defining and predicting ‘intrauterine fetal renal failure’ in congenital lower urinary tract obstruction

Rodrigo Ruano, Adnan Safdar, Jason Au, Chester J. Koh, Patricio Gargollo, Alireza A. Shamshirsaz, Jimmy Espinoza, Darrell L. Cass, Oluyinka O. Olutoye, Olutoyin A. Olutoye, Stephen Welty, David R. Roth, Michael A. Belfort, Michael C. Braun

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The aim of this study was to identify predictors of ‘intrauterine fetal renal failure’ in fetuses with severe congenital lower urinary tract obstruction (LUTO). Methods: We undertook a retrospective study of 31 consecutive fetuses with a diagnosis of LUTO in a tertiary Fetal Center between April 2013 and April 2015. Predictors of ‘intrauterine fetal renal failure’ were evaluated in those infants with severe LUTO who had either a primary composite outcome measure of neonatal death in the first 24 h of life due to severe pulmonary hypoplasia or a need for renal replacement therapy within 7 days of life. The following variables were analyzed: fetal bladder re-expansion 48 h after vesicocentesis, fetal renal ultrasound characteristics, fetal urinary indices, and amniotic fluid volume. Results: Of the 31 fetuses included in the study, eight met the criteria for ‘intrauterine fetal renal failure’. All of the latter had composite poor postnatal outcomes based on death within 24 h of life (n = 6) or need for dialysis within 1 week of life (n = 2). The percentage of fetal bladder refilling after vesicocentesis at time of initial evaluation was the only predictor of ‘intrauterine fetal renal failure’ (cut-off <27 %, area under the time–concentration curve 0.86, 95 % confidence interval 0.68–0.99; p = 0.009). Conclusion: We propose the concept of ‘intrauterine fetal renal failure’ in fetuses with the most severe forms of LUTO. Fetal bladder refilling can be used to reliably predict ‘intrauterine fetal renal failure’, which is associated with severe pulmonary hypoplasia or the need for dialysis within a few days of life.

Original languageEnglish (US)
Pages (from-to)605-612
Number of pages8
JournalPediatric Nephrology
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Urinary Tract
Renal Insufficiency
Fetus
Urinary Bladder
Dialysis
Lung
Renal Replacement Therapy
Amniotic Fluid
Area Under Curve
Retrospective Studies
Outcome Assessment (Health Care)
Confidence Intervals
Kidney

Keywords

  • Fetal lower urinary tract obstruction
  • Fetal surgery
  • Posterior urethral valves
  • Prenatal diagnosis
  • Renal function
  • Ultrasonography
  • Vesicoamniotic shunt

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Defining and predicting ‘intrauterine fetal renal failure’ in congenital lower urinary tract obstruction. / Ruano, Rodrigo; Safdar, Adnan; Au, Jason; Koh, Chester J.; Gargollo, Patricio; Shamshirsaz, Alireza A.; Espinoza, Jimmy; Cass, Darrell L.; Olutoye, Oluyinka O.; Olutoye, Olutoyin A.; Welty, Stephen; Roth, David R.; Belfort, Michael A.; Braun, Michael C.

In: Pediatric Nephrology, Vol. 31, No. 4, 01.04.2016, p. 605-612.

Research output: Contribution to journalArticle

Ruano, R, Safdar, A, Au, J, Koh, CJ, Gargollo, P, Shamshirsaz, AA, Espinoza, J, Cass, DL, Olutoye, OO, Olutoye, OA, Welty, S, Roth, DR, Belfort, MA & Braun, MC 2016, 'Defining and predicting ‘intrauterine fetal renal failure’ in congenital lower urinary tract obstruction', Pediatric Nephrology, vol. 31, no. 4, pp. 605-612. https://doi.org/10.1007/s00467-015-3246-8
Ruano, Rodrigo ; Safdar, Adnan ; Au, Jason ; Koh, Chester J. ; Gargollo, Patricio ; Shamshirsaz, Alireza A. ; Espinoza, Jimmy ; Cass, Darrell L. ; Olutoye, Oluyinka O. ; Olutoye, Olutoyin A. ; Welty, Stephen ; Roth, David R. ; Belfort, Michael A. ; Braun, Michael C. / Defining and predicting ‘intrauterine fetal renal failure’ in congenital lower urinary tract obstruction. In: Pediatric Nephrology. 2016 ; Vol. 31, No. 4. pp. 605-612.
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AU - Safdar, Adnan

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AU - Koh, Chester J.

AU - Gargollo, Patricio

AU - Shamshirsaz, Alireza A.

AU - Espinoza, Jimmy

AU - Cass, Darrell L.

AU - Olutoye, Oluyinka O.

AU - Olutoye, Olutoyin A.

AU - Welty, Stephen

AU - Roth, David R.

AU - Belfort, Michael A.

AU - Braun, Michael C.

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KW - Fetal surgery

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KW - Prenatal diagnosis

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KW - Vesicoamniotic shunt

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