Defective planar cell polarity in polycystic kidney disease

Evelyne Fischer, Emilie Legue, Antonia Doyen, Faridabano Nato, Jean François Nicolas, Vicente Torres, Moshe Yaniv, Marco Pontoglio

Research output: Contribution to journalArticle

384 Scopus citations

Abstract

Morphogenesis involves coordinated proliferation, differentiation and spatial distribution of cells. We show that lengthening of renal tubules is associated with mitotic orientation of cells along the tubule axis, demonstrating intrinsic planar cell polarization, and we demonstrate that mitotic orientations are significantly distorted in rodent polycystic kidney models. These results suggest that oriented cell division dictates the maintenance of constant tubule diameter during tubular lengthening and that defects in this process trigger renal tubular enlargement and cyst formation.

Original languageEnglish (US)
Pages (from-to)21-23
Number of pages3
JournalNature Genetics
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Genetics

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  • Cite this

    Fischer, E., Legue, E., Doyen, A., Nato, F., Nicolas, J. F., Torres, V., Yaniv, M., & Pontoglio, M. (2006). Defective planar cell polarity in polycystic kidney disease. Nature Genetics, 38(1), 21-23. https://doi.org/10.1038/ng1701