@article{88ed7c5890ac402a8745d1563ecae023,
title = "Defective planar cell polarity in polycystic kidney disease",
abstract = "Morphogenesis involves coordinated proliferation, differentiation and spatial distribution of cells. We show that lengthening of renal tubules is associated with mitotic orientation of cells along the tubule axis, demonstrating intrinsic planar cell polarization, and we demonstrate that mitotic orientations are significantly distorted in rodent polycystic kidney models. These results suggest that oriented cell division dictates the maintenance of constant tubule diameter during tubular lengthening and that defects in this process trigger renal tubular enlargement and cyst formation.",
author = "Evelyne Fischer and Emilie Legue and Antonia Doyen and Faridabano Nato and Nicolas, {Jean Fran{\c c}ois} and Vicente Torres and Moshe Yaniv and Marco Pontoglio",
note = "Funding Information: We are grateful to B. Mateescu for the H3pS10 antibody and to A. Blanchard for the aqp2 antibody. We thank E. Perret, P. Roux and M. Delarue for assistance and advice, and F. Terzi and J. Weitzman for helpful discussions and for critical reading of the manuscript. E.F. is a fellow of the Association pour l{\textquoteright}Information et la Recherche sur les maladies R{\'e}nales G{\'e}n{\'e}tiques (AIRG). This work was supported by the PKD Foundation, Genzyme Corporation and La Ligue contre le Cancer, as well as by grants (to E.L. and J.F.N.) from Cells into Organs (EU Framework 6 project LSHM-CT2003-504468), EurostemCell (EU Framework 6 project LHSB-CT2003-503005) and the Association Franc¸aise contre les Myopathies (AFM).",
year = "2006",
month = jan,
doi = "10.1038/ng1701",
language = "English (US)",
volume = "38",
pages = "21--23",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "1",
}