Abstract
Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1905-1916 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 24 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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Cite this
Heckmann, B. L., Zhang, X., Xie, X., Saarinen, A., Lu, X., Yang, X., & Liu, J. (2014). Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). Journal of Biological Chemistry, 289(4), 1905-1916. https://doi.org/10.1074/jbc.M113.522011