Abstract
Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1905-1916 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 24 2014 |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). / Heckmann, Bradlee L.; Zhang, Xiaodong; Xie, Xitao; Saarinen, Alicia; Lu, Xin; Yang, Xingyuan; Liu, Jun D.
In: Journal of Biological Chemistry, Vol. 289, No. 4, 24.01.2014, p. 1905-1916.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)
AU - Heckmann, Bradlee L.
AU - Zhang, Xiaodong
AU - Xie, Xitao
AU - Saarinen, Alicia
AU - Lu, Xin
AU - Yang, Xingyuan
AU - Liu, Jun D
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.
AB - Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=84893134937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893134937&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.522011
DO - 10.1074/jbc.M113.522011
M3 - Article
C2 - 24302733
AN - SCOPUS:84893134937
VL - 289
SP - 1905
EP - 1916
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 4
ER -