Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)

Bradlee L. Heckmann, Xiaodong Zhang, Xitao Xie, Alicia Saarinen, Xin Lu, Xingyuan Yang, Jun D Liu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.

Original languageEnglish (US)
Pages (from-to)1905-1916
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
StatePublished - Jan 24 2014

Fingerprint

Switch Genes
Lipolysis
Energy Metabolism
Genes
Switches
Fatty Acids
Thermogenesis
Lipid Metabolism
Fasting
Homeostasis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). / Heckmann, Bradlee L.; Zhang, Xiaodong; Xie, Xitao; Saarinen, Alicia; Lu, Xin; Yang, Xingyuan; Liu, Jun D.

In: Journal of Biological Chemistry, Vol. 289, No. 4, 24.01.2014, p. 1905-1916.

Research output: Contribution to journalArticle

Heckmann, Bradlee L. ; Zhang, Xiaodong ; Xie, Xitao ; Saarinen, Alicia ; Lu, Xin ; Yang, Xingyuan ; Liu, Jun D. / Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 4. pp. 1905-1916.
@article{cd25071f2fad4a6393fd97370fba0966,
title = "Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)",
abstract = "Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.",
author = "Heckmann, {Bradlee L.} and Xiaodong Zhang and Xitao Xie and Alicia Saarinen and Xin Lu and Xingyuan Yang and Liu, {Jun D}",
year = "2014",
month = "1",
day = "24",
doi = "10.1074/jbc.M113.522011",
language = "English (US)",
volume = "289",
pages = "1905--1916",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "4",

}

TY - JOUR

T1 - Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)

AU - Heckmann, Bradlee L.

AU - Zhang, Xiaodong

AU - Xie, Xitao

AU - Saarinen, Alicia

AU - Lu, Xin

AU - Yang, Xingyuan

AU - Liu, Jun D

PY - 2014/1/24

Y1 - 2014/1/24

N2 - Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.

AB - Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=84893134937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893134937&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.522011

DO - 10.1074/jbc.M113.522011

M3 - Article

C2 - 24302733

AN - SCOPUS:84893134937

VL - 289

SP - 1905

EP - 1916

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 4

ER -