Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)

Bradlee L. Heckmann, Xiaodong Zhang, Xitao Xie, Alicia Saarinen, Xin Lu, Xingyuan Yang, Jun Liu

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.

Original languageEnglish (US)
Pages (from-to)1905-1916
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
StatePublished - Jan 24 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)'. Together they form a unique fingerprint.

  • Cite this