Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)

Bradlee L. Heckmann; Xiaodong Zhang; Xitao Xie; Alicia Saarinen; Xin Lu; Xingyuan Yang; Jun Liu

doi:10.1074/jbc.M113.522011

Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)

Bradlee L. Heckmann, Xiaodong Zhang, Xitao Xie, Alicia Saarinen, Xin Lu, Xingyuan Yang, Jun Liu

Phoenix/Scottsdale, AZ

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.

Original language	English (US)
Pages (from-to)	1905-1916
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	4
DOIs	https://doi.org/10.1074/jbc.M113.522011
State	Published - Jan 24 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). / Heckmann, Bradlee L.; Zhang, Xiaodong; Xie, Xitao; Saarinen, Alicia; Lu, Xin; Yang, Xingyuan; Liu, Jun.

In: Journal of Biological Chemistry, Vol. 289, No. 4, 24.01.2014, p. 1905-1916.

Research output: Contribution to journal › Article › peer-review

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AU - Saarinen, Alicia

AU - Lu, Xin

AU - Yang, Xingyuan

AU - Liu, Jun

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