Abstract
Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.
Original language | English (US) |
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Pages (from-to) | 1905-1916 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 4 |
DOIs | |
State | Published - Jan 24 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology