TY - JOUR
T1 - Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)
AU - Heckmann, Bradlee L.
AU - Zhang, Xiaodong
AU - Xie, Xitao
AU - Saarinen, Alicia
AU - Lu, Xin
AU - Yang, Xingyuan
AU - Liu, Jun
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.
AB - Background: G0S2 has been shown in vitro to be a selective inhibitor of ATGL. Results: Adipose overexpression of G0S2 leads to decreased adipose lipolysis, impeded fatty acid utilization upon fasting, and impaired cold-induced thermogenesis. Conclusion: G0S2 plays a major role in regulating global lipid and energy metabolism. Significance: Adipose lipolysis and fatty acid liberation is crucial for energy homeostasis.
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U2 - 10.1074/jbc.M113.522011
DO - 10.1074/jbc.M113.522011
M3 - Article
C2 - 24302733
AN - SCOPUS:84893134937
VL - 289
SP - 1905
EP - 1916
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 4
ER -