Deep-wound and organ-space infection after surgery for degenerative spine disease: an analysis from 2006 to 2012

Rafael De la Garza-Ramos, Nicholas B. Abt, Panagiotis Kerezoudis, Brandon A. McCutcheon, Ali Bydon, Ziya Gokaslan, Mohamad Bydon

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To study the incidence and risk factors of deep-wound and organ-space surgical site infection (SSI) following surgery for degenerative spine disease. Methods: Data from the American College of Surgeons National Surgical Quality Improvement Program were obtained for the years 2006–2012. All adult patients over 40 years of age who underwent elective cervical or lumbar spine surgery for degenerative spine disease were identified. Rates of deep-wound and organ-space SSI were calculated for each procedure. A multivariate logistic regression analysis was conducted to identify independent risk factors for SSI development. Results: A total of 36,440 patients were identified, with 7,627 patients (20.93%) undergoing cervical spine surgery and 28,813 patients (79.07%) undergoing lumbar spine surgery. The overall rate of SSI was 0.72% (n = 264); there were 189 deep-wound infections (0.52%) and 75 organ-space infections (0.21%). The highest rates of SSI were for patients undergoing a posterolateral fusion of the lumbar spine (1.04%), followed by patients undergoing a posterior cervical decompression (1.02%); the lowest rates were for patients undergoing cervical disc replacement (0.00%). The multivariate analysis revealed that chronic steroid use (OR 3.66) and increasing operative time (OR 1.002) were the strongest independent risk factors for SSI development in the cervical spine, and renal morbidity (OR 3.93), hemato-oncological morbidity (OR 2.55), and chronic steroid use (2.04) were the strongest risk factors for lumbar SSI. Additionally, patients with a SSI had longer lengths of stay and higher mortality rates (0.76%) when compared to patients without a SSI (0.09%). Conclusion: Deep-wound and organ-space infections are severe complications in patients undergoing spine surgery. In this study of a multi-centre and prospectively collected database, the rate of SSI was 0.72%. Patients with renal disorders, chronic steroid use, hemato-oncological disease, and diabetes, among others, had significantly higher odds of SSI development.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalNeurological Research
Volume38
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Surgical Wound Infection
Spine
Wounds and Injuries
Infection
Steroids
Morbidity
Kidney
Wound Infection
Operative Time
Quality Improvement
Decompression
Length of Stay
Cohort Studies
Multivariate Analysis
Logistic Models
Regression Analysis

Keywords

  • cervical
  • deep-wound infection
  • fusion
  • lumbar
  • NSQIP
  • organ-space infection
  • Spine
  • surgery
  • surgical site infection

ASJC Scopus subject areas

  • Medicine(all)
  • Neurology
  • Clinical Neurology

Cite this

De la Garza-Ramos, R., Abt, N. B., Kerezoudis, P., McCutcheon, B. A., Bydon, A., Gokaslan, Z., & Bydon, M. (2016). Deep-wound and organ-space infection after surgery for degenerative spine disease: an analysis from 2006 to 2012. Neurological Research, 38(2), 117-123. https://doi.org/10.1080/01616412.2016.1138669

Deep-wound and organ-space infection after surgery for degenerative spine disease : an analysis from 2006 to 2012. / De la Garza-Ramos, Rafael; Abt, Nicholas B.; Kerezoudis, Panagiotis; McCutcheon, Brandon A.; Bydon, Ali; Gokaslan, Ziya; Bydon, Mohamad.

In: Neurological Research, Vol. 38, No. 2, 01.02.2016, p. 117-123.

Research output: Contribution to journalArticle

De la Garza-Ramos, R, Abt, NB, Kerezoudis, P, McCutcheon, BA, Bydon, A, Gokaslan, Z & Bydon, M 2016, 'Deep-wound and organ-space infection after surgery for degenerative spine disease: an analysis from 2006 to 2012', Neurological Research, vol. 38, no. 2, pp. 117-123. https://doi.org/10.1080/01616412.2016.1138669
De la Garza-Ramos, Rafael ; Abt, Nicholas B. ; Kerezoudis, Panagiotis ; McCutcheon, Brandon A. ; Bydon, Ali ; Gokaslan, Ziya ; Bydon, Mohamad. / Deep-wound and organ-space infection after surgery for degenerative spine disease : an analysis from 2006 to 2012. In: Neurological Research. 2016 ; Vol. 38, No. 2. pp. 117-123.
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abstract = "Objective: To study the incidence and risk factors of deep-wound and organ-space surgical site infection (SSI) following surgery for degenerative spine disease. Methods: Data from the American College of Surgeons National Surgical Quality Improvement Program were obtained for the years 2006–2012. All adult patients over 40 years of age who underwent elective cervical or lumbar spine surgery for degenerative spine disease were identified. Rates of deep-wound and organ-space SSI were calculated for each procedure. A multivariate logistic regression analysis was conducted to identify independent risk factors for SSI development. Results: A total of 36,440 patients were identified, with 7,627 patients (20.93{\%}) undergoing cervical spine surgery and 28,813 patients (79.07{\%}) undergoing lumbar spine surgery. The overall rate of SSI was 0.72{\%} (n = 264); there were 189 deep-wound infections (0.52{\%}) and 75 organ-space infections (0.21{\%}). The highest rates of SSI were for patients undergoing a posterolateral fusion of the lumbar spine (1.04{\%}), followed by patients undergoing a posterior cervical decompression (1.02{\%}); the lowest rates were for patients undergoing cervical disc replacement (0.00{\%}). The multivariate analysis revealed that chronic steroid use (OR 3.66) and increasing operative time (OR 1.002) were the strongest independent risk factors for SSI development in the cervical spine, and renal morbidity (OR 3.93), hemato-oncological morbidity (OR 2.55), and chronic steroid use (2.04) were the strongest risk factors for lumbar SSI. Additionally, patients with a SSI had longer lengths of stay and higher mortality rates (0.76{\%}) when compared to patients without a SSI (0.09{\%}). Conclusion: Deep-wound and organ-space infections are severe complications in patients undergoing spine surgery. In this study of a multi-centre and prospectively collected database, the rate of SSI was 0.72{\%}. Patients with renal disorders, chronic steroid use, hemato-oncological disease, and diabetes, among others, had significantly higher odds of SSI development.",
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N2 - Objective: To study the incidence and risk factors of deep-wound and organ-space surgical site infection (SSI) following surgery for degenerative spine disease. Methods: Data from the American College of Surgeons National Surgical Quality Improvement Program were obtained for the years 2006–2012. All adult patients over 40 years of age who underwent elective cervical or lumbar spine surgery for degenerative spine disease were identified. Rates of deep-wound and organ-space SSI were calculated for each procedure. A multivariate logistic regression analysis was conducted to identify independent risk factors for SSI development. Results: A total of 36,440 patients were identified, with 7,627 patients (20.93%) undergoing cervical spine surgery and 28,813 patients (79.07%) undergoing lumbar spine surgery. The overall rate of SSI was 0.72% (n = 264); there were 189 deep-wound infections (0.52%) and 75 organ-space infections (0.21%). The highest rates of SSI were for patients undergoing a posterolateral fusion of the lumbar spine (1.04%), followed by patients undergoing a posterior cervical decompression (1.02%); the lowest rates were for patients undergoing cervical disc replacement (0.00%). The multivariate analysis revealed that chronic steroid use (OR 3.66) and increasing operative time (OR 1.002) were the strongest independent risk factors for SSI development in the cervical spine, and renal morbidity (OR 3.93), hemato-oncological morbidity (OR 2.55), and chronic steroid use (2.04) were the strongest risk factors for lumbar SSI. Additionally, patients with a SSI had longer lengths of stay and higher mortality rates (0.76%) when compared to patients without a SSI (0.09%). Conclusion: Deep-wound and organ-space infections are severe complications in patients undergoing spine surgery. In this study of a multi-centre and prospectively collected database, the rate of SSI was 0.72%. Patients with renal disorders, chronic steroid use, hemato-oncological disease, and diabetes, among others, had significantly higher odds of SSI development.

AB - Objective: To study the incidence and risk factors of deep-wound and organ-space surgical site infection (SSI) following surgery for degenerative spine disease. Methods: Data from the American College of Surgeons National Surgical Quality Improvement Program were obtained for the years 2006–2012. All adult patients over 40 years of age who underwent elective cervical or lumbar spine surgery for degenerative spine disease were identified. Rates of deep-wound and organ-space SSI were calculated for each procedure. A multivariate logistic regression analysis was conducted to identify independent risk factors for SSI development. Results: A total of 36,440 patients were identified, with 7,627 patients (20.93%) undergoing cervical spine surgery and 28,813 patients (79.07%) undergoing lumbar spine surgery. The overall rate of SSI was 0.72% (n = 264); there were 189 deep-wound infections (0.52%) and 75 organ-space infections (0.21%). The highest rates of SSI were for patients undergoing a posterolateral fusion of the lumbar spine (1.04%), followed by patients undergoing a posterior cervical decompression (1.02%); the lowest rates were for patients undergoing cervical disc replacement (0.00%). The multivariate analysis revealed that chronic steroid use (OR 3.66) and increasing operative time (OR 1.002) were the strongest independent risk factors for SSI development in the cervical spine, and renal morbidity (OR 3.93), hemato-oncological morbidity (OR 2.55), and chronic steroid use (2.04) were the strongest risk factors for lumbar SSI. Additionally, patients with a SSI had longer lengths of stay and higher mortality rates (0.76%) when compared to patients without a SSI (0.09%). Conclusion: Deep-wound and organ-space infections are severe complications in patients undergoing spine surgery. In this study of a multi-centre and prospectively collected database, the rate of SSI was 0.72%. Patients with renal disorders, chronic steroid use, hemato-oncological disease, and diabetes, among others, had significantly higher odds of SSI development.

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KW - Spine

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