TY - JOUR
T1 - Deep brain stimulation
T2 - Technology at the cutting edge
AU - Shah, Rahul S.
AU - Chang, Su Youne
AU - Min, Hoon Ki
AU - Cho, Zang Hee
AU - Blaha, Charles D.
AU - Lee, Kendall H.
PY - 2010/12
Y1 - 2010/12
N2 - Deep brain stimulation (DBS) surgery has been performed in over 75,000 people worldwide, and has been shown to be an effective treatment for Parkinson's disease, tremor, dystonia, epilepsy, depression, Tourette's syndrome, and obsessive compulsive disorder. We review current and em-erging evidence for the role of DBS in the management of a range of neurological and psychiatric conditions, and discuss the technical and practical aspects of performing DBS surgery. In the future, evolution of DBS technology may depend on several key areas, including better scientific understanding of its underlying mechanism of action, advances in high-spatial resolution imaging and development of novel electrophysiological and neurotransmitter microsensor systems. Such de-velopments could form the basis of an intelligent closed-loop DBS system with feedback-guided neuromodulation to optimize both electrode placement and therapeutic efficacy.
AB - Deep brain stimulation (DBS) surgery has been performed in over 75,000 people worldwide, and has been shown to be an effective treatment for Parkinson's disease, tremor, dystonia, epilepsy, depression, Tourette's syndrome, and obsessive compulsive disorder. We review current and em-erging evidence for the role of DBS in the management of a range of neurological and psychiatric conditions, and discuss the technical and practical aspects of performing DBS surgery. In the future, evolution of DBS technology may depend on several key areas, including better scientific understanding of its underlying mechanism of action, advances in high-spatial resolution imaging and development of novel electrophysiological and neurotransmitter microsensor systems. Such de-velopments could form the basis of an intelligent closed-loop DBS system with feedback-guided neuromodulation to optimize both electrode placement and therapeutic efficacy.
KW - Deep brain stimulation
KW - Mechanism of action
KW - Parkinson's disease
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U2 - 10.3988/jcn.2010.6.4.167
DO - 10.3988/jcn.2010.6.4.167
M3 - Review article
C2 - 21264197
AN - SCOPUS:78651502924
SN - 1738-6586
VL - 6
SP - 167
EP - 182
JO - Journal of Clinical Neurology (Korea)
JF - Journal of Clinical Neurology (Korea)
IS - 4
ER -