Deep brain stimulation for tourette's syndrome: The case for targeting the thalamic centromedian-parafascicular complex

Paola Testini, Hoon Ki Min, Asif Bashir, Kendall H Lee

Research output: Contribution to journalShort survey

14 Scopus citations

Abstract

Tourette's syndrome (TS) is a neurologic condition characterized by both motor and phonic tics and is typically associated with psychiatric comorbidities, including obsessive-compulsive disorder/behavior and attention-deficit hyperactivity disorder, and can be psychologically and socially debilitating. It is considered a disorder of the cortico-striato-thalamo-cortical circuitry, as suggested by pathophysiology studies and therapeutic options. Among these, deep brain stimulation (DBS) of the centromedian-parafascicular nucleus (CM-Pf) of the thalamus is emerging as a valuable treatment modality for patients affected by severe, treatment-resistant TS. Here, we review the most recent experimental evidence for the pivotal role of CM-Pf in the pathophysiology of TS, discuss potential mechanisms of action that may mediate the effects of CM-Pf DBS in TS, and summarize its clinical efficacy.

Original languageEnglish (US)
Article number193
JournalFrontiers in Neurology
Volume7
Issue numberNOV
DOIs
StatePublished - Nov 10 2016

Keywords

  • Centromedian-parafascicular
  • CM-Pf
  • DBS
  • Thalamus
  • Tics
  • Tourette

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Deep brain stimulation for tourette's syndrome: The case for targeting the thalamic centromedian-parafascicular complex'. Together they form a unique fingerprint.

  • Cite this