Deep brain stimulation and cognitive outcomes among patients with Parkinson’s disease: A historical cohort study

Allison L. Hansen, Janina Krell-Roesch, Kristin A. Kirlin, Martin M. Limback-Stokin, Kimberly Roesler, Stefanie N. Velgos, Mark K. Lyons, Yonas E. Geda, Shyamal H. Mehta

Research output: Contribution to journalArticle

Abstract

Objective: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson’s disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson’s disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17). Methods: The authors i nvesti gated di fferences i n four neuropsychol ogi cal test scores at 6 months post-DBS (follow-up) as compared with baseline (i.e., Boston Naming Test, WAIS Verbal Comprehension Index [WAIS-VCI], Working Memory Index [WAIS-WMI], and Processing Speed Index [WAIS-PSI]). Results: GPi DBS patients showed no difference between baseline and follow-up on any neuropsychological test. STN DBS patients had lower scores indicating decreased performance at follow-up as compared with baseline on WAIS-PSI (mean [SD], 91.47 [10.42] versus 81.65 [12.03]; p=0.03). There was a significant (p=0.008) difference between the change in baseline to follow-up scores on the WAIS-VCI for the STN DBS and GPi DBS groups (i.e., STN DBS patients scored lower at the 6-month follow-up compared with baseline, whereas GPi DBS patients scored higher). Conclusions: GPi may be a preferred target for DBS in patients with Parkinson’s disease when considering cognitive outcomes.

Original languageEnglish (US)
Pages (from-to)196-200
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume31
Issue number3
DOIs
StatePublished - Jul 2019

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Deep Brain Stimulation
Parkinson Disease
Cohort Studies
Subthalamic Nucleus
Globus Pallidus
Neuropsychological Tests
Short-Term Memory
Cognition

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Deep brain stimulation and cognitive outcomes among patients with Parkinson’s disease : A historical cohort study. / Hansen, Allison L.; Krell-Roesch, Janina; Kirlin, Kristin A.; Limback-Stokin, Martin M.; Roesler, Kimberly; Velgos, Stefanie N.; Lyons, Mark K.; Geda, Yonas E.; Mehta, Shyamal H.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 31, No. 3, 07.2019, p. 196-200.

Research output: Contribution to journalArticle

Hansen, Allison L. ; Krell-Roesch, Janina ; Kirlin, Kristin A. ; Limback-Stokin, Martin M. ; Roesler, Kimberly ; Velgos, Stefanie N. ; Lyons, Mark K. ; Geda, Yonas E. ; Mehta, Shyamal H. / Deep brain stimulation and cognitive outcomes among patients with Parkinson’s disease : A historical cohort study. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2019 ; Vol. 31, No. 3. pp. 196-200.
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abstract = "Objective: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson’s disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson’s disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17). Methods: The authors i nvesti gated di fferences i n four neuropsychol ogi cal test scores at 6 months post-DBS (follow-up) as compared with baseline (i.e., Boston Naming Test, WAIS Verbal Comprehension Index [WAIS-VCI], Working Memory Index [WAIS-WMI], and Processing Speed Index [WAIS-PSI]). Results: GPi DBS patients showed no difference between baseline and follow-up on any neuropsychological test. STN DBS patients had lower scores indicating decreased performance at follow-up as compared with baseline on WAIS-PSI (mean [SD], 91.47 [10.42] versus 81.65 [12.03]; p=0.03). There was a significant (p=0.008) difference between the change in baseline to follow-up scores on the WAIS-VCI for the STN DBS and GPi DBS groups (i.e., STN DBS patients scored lower at the 6-month follow-up compared with baseline, whereas GPi DBS patients scored higher). Conclusions: GPi may be a preferred target for DBS in patients with Parkinson’s disease when considering cognitive outcomes.",
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AU - Hansen, Allison L.

AU - Krell-Roesch, Janina

AU - Kirlin, Kristin A.

AU - Limback-Stokin, Martin M.

AU - Roesler, Kimberly

AU - Velgos, Stefanie N.

AU - Lyons, Mark K.

AU - Geda, Yonas E.

AU - Mehta, Shyamal H.

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N2 - Objective: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson’s disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson’s disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17). Methods: The authors i nvesti gated di fferences i n four neuropsychol ogi cal test scores at 6 months post-DBS (follow-up) as compared with baseline (i.e., Boston Naming Test, WAIS Verbal Comprehension Index [WAIS-VCI], Working Memory Index [WAIS-WMI], and Processing Speed Index [WAIS-PSI]). Results: GPi DBS patients showed no difference between baseline and follow-up on any neuropsychological test. STN DBS patients had lower scores indicating decreased performance at follow-up as compared with baseline on WAIS-PSI (mean [SD], 91.47 [10.42] versus 81.65 [12.03]; p=0.03). There was a significant (p=0.008) difference between the change in baseline to follow-up scores on the WAIS-VCI for the STN DBS and GPi DBS groups (i.e., STN DBS patients scored lower at the 6-month follow-up compared with baseline, whereas GPi DBS patients scored higher). Conclusions: GPi may be a preferred target for DBS in patients with Parkinson’s disease when considering cognitive outcomes.

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