Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland

Toshitaka Nagao, Thomas A. Gaffey, Paul A. Kay, Krishnan K. Unni, Antonio G. Nascimento, Thomas J. Sebo, Hiromi Serizawa, Hiroshi Minato, Jean E. Lewis

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Mucoepidermoid carcinoma (MEC), a common malignant salivary gland neoplasm, is generally divided into low-, intermediate-, and high-grade types according to the histologic features. To our knowledge, the present report describes the first case of dedifferentiation occurring in a low-grade MEC. A 55-year-old man presented with a biphasic neoplasm of the right parotid gland composed of low-grade MEC and dedifferentiated high-grade anaplastic undifferentiated carcinoma. Immunohistochemically, carcinoembryonic antigen expression was restricted to the low-grade MEC portion. The Ki-67-labeling index was higher in the dedifferentiated component than in the low-grade component. On image cytometric analysis, the low-grade MEC was diploid, whereas the dedifferentiated carcinoma was aneuploid. Although the patient was alive 10 years after the initial diagnosis, the tumor has recurred twice, at 3 months and 7 months after the initial resection. It is important to recognize that dedifferentiation can occur in a low-grade MEC, similar to other low-grade salivary gland carcinomas.

Original languageEnglish (US)
Pages (from-to)1068-1072
Number of pages5
JournalHuman Pathology
Volume34
Issue number10
DOIs
StatePublished - Oct 2003

Keywords

  • Case history
  • Dedifferentiation
  • Mucoepidermoid carcinoma
  • Salivary gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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