Decreased treatment failure in recipients of HLA-identical bone marrow or peripheral blood stem cell transplants with high CD34 cell doses

Olle Ringdén, A. John Barrett, Mei Jie Zhang, Fausto R. Loberiza, Brian J. Bolwell, Mitchell S. Cairo, Robert Peter Gale, Gregory A. Hale, Mark R Litzow, Rodrigo Martino, James A. Russell, Pierre Tiberghien, Alvaro Urbano-Ispizua, Mary M. Horowitz

Research output: Contribution to journalArticle

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Abstract

We studied the association between CD34 cell dose and transplant outcomes in 359 bone marrow (BM) and 511 peripheral blood stem cell (PBSC) transplant recipients from human leucocyte antigen (HLA)-identical siblings, reported to the International Bone Marrow Transplant Registry (IBMTR). Transplants for leukaemia were performed between 1995 and 1998. Patients were divided into those receiving below or above the median CD34+ dose, for BM (3 × 106/kg) and PBSC (6 × 106/kg) grafts respectively. Cox proportional hazards regression was used to adjust for baseline patient-, disease- and transplant-related characteristics. Analysis of the BM recipients showed that high CD34 cell dose was associated with lower transplant-related mortality [relative risk (RR)= 0.60, P = 0.033] and treatment failure (inverse of leukaemia-free survival, RR = 0.69. P = 0.032). Among PBSC recipients, high CD34 dose was associated with faster recovery of neutrophils to > 0.5 × 109/l (RR = 1.38, P < 0.001) and platelets to > 20 × 109/l (RR = 1.34, P = 0.003), lower risk of relapse (RR = 0.62, P = 0.029) and treatment failure (RR = 0.74, P = 0.03). We conclude that higher CD34 cell doses decrease treatment failure in recipients of HLA-identical sibling BM and PBSC transplants.

Original languageEnglish (US)
Pages (from-to)874-885
Number of pages12
JournalBritish Journal of Haematology
Volume121
Issue number6
DOIs
StatePublished - Jun 2003

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HLA Antigens
Treatment Failure
Bone Marrow
Transplants
Siblings
Leukemia
Peripheral Blood Stem Cells
Registries
Neutrophils
Recurrence
Survival
Mortality

Keywords

  • Allogeneic
  • CD34
  • Graft type
  • Leukaemia
  • Transplantation

ASJC Scopus subject areas

  • Hematology

Cite this

Decreased treatment failure in recipients of HLA-identical bone marrow or peripheral blood stem cell transplants with high CD34 cell doses. / Ringdén, Olle; John Barrett, A.; Zhang, Mei Jie; Loberiza, Fausto R.; Bolwell, Brian J.; Cairo, Mitchell S.; Gale, Robert Peter; Hale, Gregory A.; Litzow, Mark R; Martino, Rodrigo; Russell, James A.; Tiberghien, Pierre; Urbano-Ispizua, Alvaro; Horowitz, Mary M.

In: British Journal of Haematology, Vol. 121, No. 6, 06.2003, p. 874-885.

Research output: Contribution to journalArticle

Ringdén, O, John Barrett, A, Zhang, MJ, Loberiza, FR, Bolwell, BJ, Cairo, MS, Gale, RP, Hale, GA, Litzow, MR, Martino, R, Russell, JA, Tiberghien, P, Urbano-Ispizua, A & Horowitz, MM 2003, 'Decreased treatment failure in recipients of HLA-identical bone marrow or peripheral blood stem cell transplants with high CD34 cell doses', British Journal of Haematology, vol. 121, no. 6, pp. 874-885. https://doi.org/10.1046/j.1365-2141.2003.04364.x
Ringdén, Olle ; John Barrett, A. ; Zhang, Mei Jie ; Loberiza, Fausto R. ; Bolwell, Brian J. ; Cairo, Mitchell S. ; Gale, Robert Peter ; Hale, Gregory A. ; Litzow, Mark R ; Martino, Rodrigo ; Russell, James A. ; Tiberghien, Pierre ; Urbano-Ispizua, Alvaro ; Horowitz, Mary M. / Decreased treatment failure in recipients of HLA-identical bone marrow or peripheral blood stem cell transplants with high CD34 cell doses. In: British Journal of Haematology. 2003 ; Vol. 121, No. 6. pp. 874-885.
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AU - Ringdén, Olle

AU - John Barrett, A.

AU - Zhang, Mei Jie

AU - Loberiza, Fausto R.

AU - Bolwell, Brian J.

AU - Cairo, Mitchell S.

AU - Gale, Robert Peter

AU - Hale, Gregory A.

AU - Litzow, Mark R

AU - Martino, Rodrigo

AU - Russell, James A.

AU - Tiberghien, Pierre

AU - Urbano-Ispizua, Alvaro

AU - Horowitz, Mary M.

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N2 - We studied the association between CD34 cell dose and transplant outcomes in 359 bone marrow (BM) and 511 peripheral blood stem cell (PBSC) transplant recipients from human leucocyte antigen (HLA)-identical siblings, reported to the International Bone Marrow Transplant Registry (IBMTR). Transplants for leukaemia were performed between 1995 and 1998. Patients were divided into those receiving below or above the median CD34+ dose, for BM (3 × 106/kg) and PBSC (6 × 106/kg) grafts respectively. Cox proportional hazards regression was used to adjust for baseline patient-, disease- and transplant-related characteristics. Analysis of the BM recipients showed that high CD34 cell dose was associated with lower transplant-related mortality [relative risk (RR)= 0.60, P = 0.033] and treatment failure (inverse of leukaemia-free survival, RR = 0.69. P = 0.032). Among PBSC recipients, high CD34 dose was associated with faster recovery of neutrophils to > 0.5 × 109/l (RR = 1.38, P < 0.001) and platelets to > 20 × 109/l (RR = 1.34, P = 0.003), lower risk of relapse (RR = 0.62, P = 0.029) and treatment failure (RR = 0.74, P = 0.03). We conclude that higher CD34 cell doses decrease treatment failure in recipients of HLA-identical sibling BM and PBSC transplants.

AB - We studied the association between CD34 cell dose and transplant outcomes in 359 bone marrow (BM) and 511 peripheral blood stem cell (PBSC) transplant recipients from human leucocyte antigen (HLA)-identical siblings, reported to the International Bone Marrow Transplant Registry (IBMTR). Transplants for leukaemia were performed between 1995 and 1998. Patients were divided into those receiving below or above the median CD34+ dose, for BM (3 × 106/kg) and PBSC (6 × 106/kg) grafts respectively. Cox proportional hazards regression was used to adjust for baseline patient-, disease- and transplant-related characteristics. Analysis of the BM recipients showed that high CD34 cell dose was associated with lower transplant-related mortality [relative risk (RR)= 0.60, P = 0.033] and treatment failure (inverse of leukaemia-free survival, RR = 0.69. P = 0.032). Among PBSC recipients, high CD34 dose was associated with faster recovery of neutrophils to > 0.5 × 109/l (RR = 1.38, P < 0.001) and platelets to > 20 × 109/l (RR = 1.34, P = 0.003), lower risk of relapse (RR = 0.62, P = 0.029) and treatment failure (RR = 0.74, P = 0.03). We conclude that higher CD34 cell doses decrease treatment failure in recipients of HLA-identical sibling BM and PBSC transplants.

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