Decreased Skeletal Muscle Mass is Associated with an Increased Risk of Mortality after Radical Nephrectomy for Localized Renal Cell Cancer

Sarah P. Psutka, Stephen A. Boorjian, Michael R. Moynagh, Grant D. Schmit, Brian Costello, R. Houston Thompson, Suzanne B. Stewart-Merrill, Christine M. Lohse, John C. Cheville, Bradley C. Leibovich, Matthew K. Tollefson

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Purpose We evaluate the association between severe skeletal muscle deficiency or sarcopenia, and disease progression, cancer specific mortality and all cause mortality in patients with localized renal cell carcinoma treated with radical nephrectomy. Materials and Methods The baseline lumbar skeletal muscle index of 387 patients treated with radical nephrectomy for nonmetastatic renal cell carcinoma between 2000 and 2010 was measured on preoperative computerized tomography. Sarcopenia was classified according to gender specific consensus definitions as male - skeletal muscle index less than 55 cm2/m2 and female - skeletal muscle index less than 39 cm2/m2. Progression-free, cancer specific and overall survival was estimated with the Kaplan-Meier method. Associations with progression, cancer specific mortality and all cause mortality were summarized with hazard ratios. Results Of 387 patients 180 (47%) had sarcopenia. Patients with sarcopenia were older, more likely to be male (77% vs 56%, p

Original languageEnglish (US)
Pages (from-to)270-276
Number of pages7
JournalJournal of Urology
Volume195
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • body mass index
  • carcinoma
  • nephrectomy
  • renal cell
  • sarcopenia
  • survival rate

ASJC Scopus subject areas

  • Urology

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