Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects

Gloria Formoso, Elena Anna De Filippis, Noemi Michetti, Patrizia Di Fulvio, Assunta Pandolfi, Tonino Bucciarelli, Giovanni Ciabattoni, Antonio Nicolucci, Giovanni Davì, Agostino Consoli

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Background: In type 2 diabetes, metformin reduces cardiovascular risk beyond the effect of glycaemic control. Since oxidative stress and the consequent enhanced platelet activation contribute to accelerated atherosclerosis in diabetes, we hypothesized that metformin could reduce oxidative stress in this condition. Methods: We randomized 26 newly diagnosed type 2 diabetic subjects to assume either metformin (M, n = 13) or gliclazide (G, n = 13) for 12 weeks. Drugs were titrated as needed to achieve good glycaemic control. Before and after treatment, we determined blood glucose, insulin, HbA1c, vitamin A and E levels and 8-iso-PGF and 11-dehydro-thromboxane B2 urinary excretion, an in vivo oxidative stress and a thromboxane-dependent platelet activation marker, respectively. Results: Notwithstanding a comparable improvement in metabolic control, 8-iso-PGF (M from 708 ± 32 to 589 ± 45 pg/mg cr, p < 0.001; G from 646 ± 80 to 665 ± 79, pg/mg cr, p = ns) and 11-dehydro-thromboxane B2 (M from 2190 ± 196 to 1753 ± 150 pg/mg cr, p < 0.05; G from 2048 ± 202 to 1923 ± 223, pg/mg cr, p = ns) urinary excretion decreased after metformin bur not after gliclazide treatment. After metformin, vitamin A and E levels significantly increased while they remained unchanged after gliclazide. Conclusions: These data suggest that metformin could improve oxidative stress, preserve antioxidant function and restrain platelet activation in type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume24
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

    Fingerprint

Keywords

  • Isoprostanes
  • Metformin
  • Oxidative stress
  • Platelet activation
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Formoso, G., De Filippis, E. A., Michetti, N., Di Fulvio, P., Pandolfi, A., Bucciarelli, T., Ciabattoni, G., Nicolucci, A., Davì, G., & Consoli, A. (2008). Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects. Diabetes/Metabolism Research and Reviews, 24(3), 231-237. https://doi.org/10.1002/dmrr.794